ACER2

GENERAL INFORMATION

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Gene name

ACER2

Gene description

Alkaline ceramidase 2

Protein class

Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (stomach, urinary bladder)
GTEx:Tissue enriched (urinary bladder)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression mainly in stomach and urinary bladder. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending retesting.

Data reliability

Uncertain based on 1 antibody.
HPA014092
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (stomach, urinary bladder)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (urinary bladder)

Organ

Expression



GENE INFORMATION

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Gene name

ACER2 (HGNC Symbol)

Synonyms

ASAH3L, FLJ41587

Description

Alkaline ceramidase 2 (HGNC Symbol)

Entrez gene summary

The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010]

Chromosome

9

Cytoband

p22.1

Chromosome location (bp)

19409059 - 19452020

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000177076 (version 78.38)

Entrez gene

340485

UniProt

Q5QJU3 (UniProt - Evidence at protein level)

neXtProt

NX_Q5QJU3

Antibodypedia

ACER2 antibodies


PROTEIN BROWSER

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ENST00000340967
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACER2-001 ENSP00000342609
ENST00000340967
Q5QJU3
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