LYNX1

GENERAL INFORMATION

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Gene name

LYNX1

Gene description

Ly6/neurotoxin 1

Protein class

Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

Membrane,Secreted

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (esophagus)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Strong cytoplasmic positivity was observed in exocrine pancreas, placental trophoblasts, lymphoid cells outside reaction centra and most neurons in CNS. Squamous epithelia, the intestinal tract and endocrine glands showed weak to moderate staining. The remaining normal tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA023711
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (esophagus)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

LYNX1 (HGNC Symbol)

Synonyms

SLURP2

Description

Ly6/neurotoxin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q24.3

Chromosome location (bp)

142764334 - 142778224

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000180155 (version 78.38)

Entrez gene

66004

UniProt

Q9BZG9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BZG9

Antibodypedia

LYNX1 antibodies


PROTEIN BROWSER

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ENST00000317543
 
ENST00000521396
 
ENST00000523332
 
ENST00000613110
 
ENST00000614268
 
ENST00000614491
 
ENST00000615007
 
ENST00000620006
 
ENST00000621401
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LYNX1-001 ENSP00000479586
ENST00000615007
Q9BZG9
Show all »
Show » Show » 131 14 Yes 0
LYNX1-002 ENSP00000319846
ENST00000317543
Q9BZG9
Show all »
Show » Show » 97 10.2 Yes 0
LYNX1-003 ENSP00000478390
ENST00000621401
Q9BZG9
Show all »
Show » Show » 116 12.6 Yes 1
LYNX1-004 ENSP00000428465
ENST00000521396
H0YB12
Show all »
Show » 87 8.9 Yes 0
LYNX1-005 ENSP00000481790
ENST00000613110
Show » 84 9.4 Yes 0
LYNX1-007 ENSP00000478402
ENST00000620006
Q9BZG9
Show all »
Show » Show » 116 12.6 Yes 1
LYNX1-008 ENSP00000482846
ENST00000614268
Show » 82 9.2 Yes 0
LYNX1-009 ENSP00000428713
ENST00000523332
G3V0Z9
Show all »
Show » 82 9 Yes 0
LYNX1-201 ENSP00000477648
ENST00000614491
Q9BZG9
Show all »
Show » Show » 116 12.6 Yes 1