LIMK2

GENERAL INFORMATION

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Gene name

LIMK2

Gene description

LIM domain kinase 2

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic and nuclear expression at variable levels.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Data reliability

Uncertain based on 3 antibodies.
HPA008183 , HPA053882 , CAB019313
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

LIMK2

Synonyms

Description

LIM domain kinase 2 (HGNC Symbol)

Entrez gene summary

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q12.2

Chromosome location (bp)

31212239 - 31280080

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000182541 (version 78.38)

Entrez gene

3985

UniProt

P53671 (UniProt - Evidence at protein level)

neXtProt

NX_P53671

Antibodypedia

LIMK2 antibodies


PROTEIN BROWSER

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ENST00000331728
 
ENST00000333611
 
ENST00000340552
 
ENST00000406516
 
ENST00000425203
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LIMK2-001 ENSP00000332687
ENST00000331728
P53671
Show all »
Show » Show » 638 72.2 No 0
LIMK2-002 ENSP00000384602
ENST00000406516
B5MC51
Show all »
Show » Show » 629 71.2 No 0
LIMK2-003 ENSP00000339916
ENST00000340552
P53671
Show all »
Show » Show » 686 77.9 No 0
LIMK2-004 ENSP00000330470
ENST00000333611
P53671
Show all »
Show » Show » 617 69.9 No 0
LIMK2-005 ENSP00000388422
ENST00000425203
C9JK61
Show all »
Show » Show » 82 9.4 No 0