CLDN6

GENERAL INFORMATION

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Gene name

CLDN6

Gene description

Claudin 6

Protein class

Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (placenta, testis)
GTEx:Tissue enhanced (cerebellum, testis)

Protein evidence

Evidence at protein level

Protein localization

General membranous expression. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Caution, targets protein from more than one gene.

Data reliability

Uncertain based on 1 antibody.
HPA007322
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (placenta, testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebellum, testis)

Organ

Expression



GENE INFORMATION

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Gene name

CLDN6

Synonyms

Description

Claudin 6 (HGNC Symbol)

Entrez gene summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

3014712 - 3020071

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184697 (version 78.38)

Entrez gene

9074

UniProt

P56747 (UniProt - Evidence at protein level)

neXtProt

NX_P56747

Antibodypedia

CLDN6 antibodies


PROTEIN BROWSER

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ENST00000328796
 
ENST00000396925
 
ENST00000572154
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLDN6-001 ENSP00000380131
ENST00000396925
P56747
Show all »
Show » Show » 220 23.3 Yes 3
CLDN6-002 ENSP00000458783
ENST00000572154
I3L1E7
Show all »
Show » Show » 39 4.1 No 0
CLDN6-201 ENSP00000328674
ENST00000328796
P56747
Show all »
Show » Show » 220 23.3 Yes 3