DEFB132

GENERAL INFORMATION

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Gene name

DEFB132

Gene description

Defensin, beta 132

Protein class

Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (adipose tissue, prostate)
GTEx:Group enriched (adipose tissue, breast, prostate)

Protein evidence

Evidence at transcript level

Protein localization

Distinct cytoplasmic expression in CNS and epididymis.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Uncertain based on 1 antibody.
HPA046399
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (adipose tissue, prostate)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (adipose tissue, breast, prostate)

Organ

Expression



GENE INFORMATION

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Gene name

DEFB132 (HGNC Symbol)

Synonyms

DEFB32, RP5-1103G7.6

Description

Defensin, beta 132 (HGNC Symbol)

Entrez gene summary

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. This protein binds spermatozoa and has antimicrobial activity against E. coli. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]

Chromosome

20

Cytoband

p13

Chromosome location (bp)

257736 - 261096

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000186458 (version 78.38)

Entrez gene

400830

UniProt

Q7Z7B7 (UniProt - Evidence at transcript level)

neXtProt

NX_Q7Z7B7

Antibodypedia

DEFB132 antibodies


PROTEIN BROWSER

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ENST00000382376
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DEFB132-001 ENSP00000371813
ENST00000382376
Q7Z7B7
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Show » Show » 95 10.6 Yes 0