KLK12

GENERAL INFORMATION

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Gene name

KLK12

Gene description

Kallikrein-related peptidase 12

Protein class

Enzymes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (esophagus)
GTEx:Group enriched (cervix, uterine, esophagus, salivary gland, vagina)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in a selected group of tissues, most abundant in esophagus. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
CAB025473
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (esophagus)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cervix, uterine, esophagus, salivary gland, vagina)

Organ

Expression



GENE INFORMATION

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Gene name

KLK12 (HGNC Symbol)

Synonyms

KLK-L5

Description

Kallikrein-related peptidase 12 (HGNC Symbol)

Entrez gene summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.41

Chromosome location (bp)

51029092 - 51035230

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186474 (version 78.38)

Entrez gene

43849

UniProt

Q9UKR0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UKR0

Antibodypedia

KLK12 antibodies


PROTEIN BROWSER

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ENST00000250351
 
ENST00000319590
 
ENST00000525263
 
ENST00000529888
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KLK12-001 ENSP00000434036
ENST00000529888
Q9UKR0
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Show » Show » 111 12 Yes 0
KLK12-005 ENSP00000436458
ENST00000525263
Q9UKR0
Show all »
Show » Show » 248 26.7 Yes 0
KLK12-008 ENSP00000250351
ENST00000250351
Q9UKR0
Show all »
Show » Show » 254 27.1 Yes 0
KLK12-201 ENSP00000324181
ENST00000319590
Q9UKR0
Show all »
Show » Show » 248 26.7 Yes 0