AKR1C1

GENERAL INFORMATION

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Gene name

AKR1C1

Gene description

Aldo-keto reductase family 1, member C1

Protein class

Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression with several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
CAB047303
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

AKR1C1 (HGNC Symbol)

Synonyms

DD1, DDH, DDH1, HAKRC, MBAB

Description

Aldo-keto reductase family 1, member C1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

p15.1

Chromosome location (bp)

4963253 - 5107522

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000187134 (version 78.38)

Entrez gene

1645

UniProt

Q04828 (UniProt - Evidence at protein level)

neXtProt

NX_Q04828

Antibodypedia

AKR1C1 antibodies


PROTEIN BROWSER

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ENST00000380859
 
ENST00000380872
 
ENST00000434459
 
ENST00000442997
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKR1C1-001 ENSP00000370254
ENST00000380872
Q04828
Show all »
Show » Show » 323 36.8 No 0
AKR1C1-003 ENSP00000416415
ENST00000442997
Show » 248 28.1 No 0
AKR1C1-004 ENSP00000370240
ENST00000380859
A6NHU4
Show all »
Show » Show » 205 23.2 Yes 0
AKR1C1-201 ENSP00000412248
ENST00000434459
Show » 324 37.1 No 0