ASAH2

GENERAL INFORMATION

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Gene name

ASAH2

Gene description

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2

Protein class

Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (duodenum, small intestine)
GTEx:Not detected

Protein evidence

Evidence at protein level

Protein localization

Distinct luminal membranous expression in small intestine and duodenum.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Data reliability

Supportive based on 1 antibody.
HPA061171
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (duodenum, small intestine)

Organ

Expression

GTEx dataset
RNA tissue category:  Not detected

Organ

Expression



GENE INFORMATION

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Gene name

ASAH2

Synonyms

Description

N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 (HGNC Symbol)

Entrez gene summary

Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008]

Chromosome

10

Cytoband

q11.23

Chromosome location (bp)

50182778 - 50248610

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000188611 (version 78.38)

Entrez gene

56624

UniProt

Q9NR71 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NR71

Antibodypedia

ASAH2 antibodies


PROTEIN BROWSER

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ENST00000329428
 
ENST00000395526
 
ENST00000443575
 
ENST00000447815
 
ENST00000489640
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ASAH2-001 ENSP00000378897
ENST00000395526
Q9NR71
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Show » Show » 780 85.5 No 0
ASAH2-003 ENSP00000329886
ENST00000329428
Q9NR71
Show all »
Show » Show » 726 79.5 Yes 0
ASAH2-004 ENSP00000476827
ENST00000489640
V9GYJ5
Show all »
Show » 144 16.2 No 0
ASAH2-201 ENSP00000392766
ENST00000443575
E9PBM9
Show all »
Show » 622 68.7 No 0
ASAH2-202 ENSP00000388206
ENST00000447815
Q9NR71
Show all »
Show » Show » 745 81.7 No 0