LAGE3

GENERAL INFORMATION

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Gene name

LAGE3

Gene description

L antigen family, member 3

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA036122 , HPA036123
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

LAGE3 (HGNC Symbol)

Synonyms

CVG5, DXS9879E, DXS9951E, ESO3, ITBA2

Description

L antigen family, member 3 (HGNC Symbol)

Entrez gene summary

This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q28

Chromosome location (bp)

154477769 - 154479257

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196976 (version 78.38)

Entrez gene

8270

UniProt

Q14657 (UniProt - Evidence at protein level)

neXtProt

NX_Q14657

Antibodypedia

LAGE3 antibodies


PROTEIN BROWSER

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ENST00000357360
 
ENST00000621786
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LAGE3-001 ENSP00000349923
ENST00000357360
Q14657
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Show » Show » 143 14.8 No 0
LAGE3-201 ENSP00000478022
ENST00000621786
Show » 105 11.3 No 0