PDGFA

GENERAL INFORMATION

? »

Gene name

PDGFA

Gene description

Platelet-derived growth factor alpha polypeptide

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Predicted intracellular proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Distinct cytoplasmic expression in several tissues.

ANTIBODY RELIABILITY

? »

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Uncertain based on 1 antibody.
CAB005579
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

PDGFA (HGNC Symbol)

Synonyms

PDGF-A, PDGF1

Description

Platelet-derived growth factor alpha polypeptide (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

p22.3

Chromosome location (bp)

497258 - 520296

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197461 (version 78.38)

Entrez gene

5154

UniProt

P04085 (UniProt - Evidence at protein level)

neXtProt

NX_P04085

Antibodypedia

PDGFA antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000354513
 
ENST00000400761
 
ENST00000402802
 
ENST00000405692
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDGFA-001 ENSP00000383889
ENST00000402802
P04085
Show all »
Show » Show » 196 22.3 Yes 0
PDGFA-002 ENSP00000346508
ENST00000354513
P04085
Show all »
Show » Show » 211 24 Yes 0
PDGFA-005 ENSP00000383572
ENST00000400761
H7BYW6
Show all »
Show » Show » 205 22.9 No 0
PDGFA-006 ENSP00000384673
ENST00000405692
Show » Show » 86 9.8 Yes 0