KEL

GENERAL INFORMATION

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Gene name

KEL

Gene description

Kell blood group, metallo-endopeptidase

Protein class

Blood group antigen proteins
Cancer-related genes
CD markers
Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (bone marrow, testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression mainly in testis and lymphoid organs. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending retesting.

Data reliability

Uncertain based on 1 antibody.
HPA042391
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (bone marrow, testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

KEL (HGNC Symbol)

Synonyms

CD238, ECE3

Description

Kell blood group, metallo-endopeptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q34

Chromosome location (bp)

142941114 - 142962681

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197993 (version 78.38)

Entrez gene

3792

UniProt

P23276 (UniProt - Evidence at protein level)

neXtProt

NX_P23276

Antibodypedia

KEL antibodies


PROTEIN BROWSER

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ENST00000355265
 
ENST00000460479
 
ENST00000467543
 
ENST00000476829
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KEL-001 ENSP00000347409
ENST00000355265
P23276
Show all »
Show » Show » 732 82.8 No 1
KEL-003 ENSP00000420011
ENST00000467543
E7ETW3
Show all »
Show » Show » 204 23 No 1
KEL-004 ENSP00000418886
ENST00000460479
A3F6J8
Show all »
Show » Show » 186 20.6 No 1
KEL-005 ENSP00000419889
ENST00000476829
E9PHG0
Show all »
Show » Show » 184 20.7 No 1