MMP17

GENERAL INFORMATION

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Gene name

MMP17

Gene description

Matrix metallopeptidase 17 (membrane-inserted)

Protein class

Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

MMP17 (HGNC Symbol)

Synonyms

MT4-MMP

Description

Matrix metallopeptidase 17 (membrane-inserted) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q24.33

Chromosome location (bp)

131828393 - 131851783

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198598 (version 78.38)

Entrez gene

4326

UniProt

Q9ULZ9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9ULZ9

Antibodypedia

MMP17 antibodies


PROTEIN BROWSER

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ENST00000360564
 
ENST00000534865
 
ENST00000535004
 
ENST00000535291
 
ENST00000542648
 
ENST00000545671
 
ENST00000545790
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP17-001 ENSP00000353767
ENST00000360564
Q9ULZ9
Show all »
Show » Show » 603 66.7 Yes 0
MMP17-002 ENSP00000441106
ENST00000535291
Q9ULZ9
Show all »
Show » Show » 519 57.9 No 0
MMP17-003 ENSP00000444603
ENST00000545671
F5GZA7
Show all »
Show » Show » 169 18.9 No 0
MMP17-004 ENSP00000441710
ENST00000545790
F5GWR3
Show all »
Show » Show » 115 13 No 0
MMP17-005 ENSP00000442104
ENST00000534865
F5H881
Show all »
Show » Show » 302 34.7 No 0
MMP17-008 ENSP00000439542
ENST00000542648
F5H249
Show all »
Show » Show » 118 14 No 0
MMP17-010 ENSP00000445620
ENST00000535004
F5H209
Show all »
Show » Show » 143 14.9 No 0