SGMS1

CANCER ATLAS

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Gene description

Sphingomyelin synthase 1

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level
 
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

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HPA045191
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 
 

Staining summary

Most malignant cells showed weak to moderate cytoplasmic positivity. Additional membranous staining was exhibited by a few colorectal, renal and occasional pancreatic cancers. Occasional colorectal, urothelial, prostate and gastric cancers were strongly positive. Several malignant melanomas, lymphomas, gliomas and testicular cancers were negative.
 

Level of antibody staining/expression





High
Medium
Low
Not detected