ITSN1

GENERAL INFORMATION

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Gene name

ITSN1

Gene description

Intersectin 1 (SH3 domain protein)

Protein class

Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

18
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA018007
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ITSN1 (HGNC Symbol)

Synonyms

ITSN, MGC134948, MGC134949, SH3D1A, SH3P17

Description

Intersectin 1 (SH3 domain protein) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]

Chromosome

21

Cytoband

q22.11

Chromosome location (bp)

33642400 - 33899861

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000205726 (version 78.38)

Entrez gene

6453

UniProt

Q15811 (UniProt - Evidence at protein level)

neXtProt

NX_Q15811

Antibodypedia

ITSN1 antibodies


PROTEIN BROWSER

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ENST00000379960
 
ENST00000381283
 
ENST00000381284
 
ENST00000381285
 
ENST00000381291
 
ENST00000381318
 
ENST00000399338
 
ENST00000399349
 
ENST00000399352
 
ENST00000399353
 
ENST00000399355
 
ENST00000399367
 
ENST00000415023
 
ENST00000437442
 
ENST00000440794
 
ENST00000444491
 
ENST00000451686
 
ENST00000456489
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITSN1-001 ENSP00000370719
ENST00000381318
Q15811
Show all »
Show » Show » 1721 195.4 No 0
ITSN1-002 ENSP00000370691
ENST00000381291
Q15811
Show all »
Show » Show » 1220 137.6 No 0
ITSN1-003 ENSP00000382286
ENST00000399349
Q15811
Show all »
Show » Show » 1144 129.4 No 0
ITSN1-004 ENSP00000370684
ENST00000381284
Q6J1T2
Show all »
Show » Show » 317 36.2 No 0
ITSN1-005 ENSP00000409800
ENST00000415023
Q6J334
Show all »
Show » Show » 173 19.8 No 0
ITSN1-017 ENSP00000411464
ENST00000456489
Show » 60 6.3 No 0
ITSN1-023 ENSP00000382301
ENST00000399367
Q15811
Show all »
Show » Show » 1716 194.8 No 0
ITSN1-024 ENSP00000382289
ENST00000399352
Q15811
Show all »
Show » Show » 1215 137 No 0
ITSN1-025 ENSP00000382290
ENST00000399353
Q15811
Show all »
Show » Show » 1178 133.6 No 0
ITSN1-030 ENSP00000396054
ENST00000440794
Q6J333
Show all »
Show » Show » 260 28.1 No 1
ITSN1-032 ENSP00000407132
ENST00000451686
C9JXS9
Show all »
Show » Show » 78 8.8 No 0
ITSN1-033 ENSP00000400079
ENST00000444491
C9J1A4
Show all »
Show » Show » 115 12.8 No 0
ITSN1-036 ENSP00000370683
ENST00000381283
C9JQZ7
Show all »
Show » Show » 361 41 No 0
ITSN1-037 ENSP00000382292
ENST00000399355
F8W7U0
Show all »
Show » Show » 1149 130 No 0
ITSN1-201 ENSP00000369294
ENST00000379960
D6PAW0
Show all »
Show » Show » 237 25.1 No 0
ITSN1-202 ENSP00000370685
ENST00000381285
A8CTZ0
Show all »
Show » Show » 877 100.7 No 0
ITSN1-203 ENSP00000382275
ENST00000399338
Q15811
Show all »
Show » Show » 1020 115.9 No 1
ITSN1-204 ENSP00000387377
ENST00000437442
D6PAW0
Show all »
Show » Show » 237 25.1 No 0