Brain tissue expression of PKM in pons - The Human Protein Atlas

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	725.8	nTPM
FANTOM5:	1335.0	Scaled Tags Per Million

Macaque:	502.8	nTPM
Mouse:	1000.5	nTPM
Rat:	0.0	nTPM
Pig:	712.5	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
Show allShow less

This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
Show allShow less

This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	725.8

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 441.6

1984	Male, age 76, both hemispheres	506.2
2301	Female, age 85, both hemispheres	458.4
2090	Male, age 80, both hemispheres	409.8
2188	Female, age 91, both hemispheres	392.1

Dorsal cochlear nucleus
nTPM: 492.7

2802	Male, age 74, right hemisphere	569.1
2058	Male, age 76, both hemispheres	515.6
2370	Male, age 61, both hemispheres	501.2
2187	Female, age 91, both hemispheres	446.2
2378	Male, age 80, both hemispheres	431.4

Dorsal tegmental nucleus
nTPM: 531.5

2358	Male, age 61, both hemispheres	630.9
2083	Male, age 80, both hemispheres	557.5
2326	Male, age 74, both hemispheres	473.1
1936	Male, age 76, left hemisphere	464.5

Dorsolateral tegmental area
nTPM: 524.6

2654	Male, age 80, both hemispheres	549.8
2141	Male, age 76, both hemispheres	525.9
2337	Male, age 61, both hemispheres	522.9
2360	Male, age 74, both hemispheres	518.7
2751	Female, age 85, both hemispheres	505.9

Kolliker-Fuse nucleus
nTPM: 557.9

2163	Male, age 80, both hemispheres	700.0
2315	Male, age 76, right hemisphere	534.6
2793	Female, age 91, left hemisphere	439.1

Lateral lemniscal nuclei
nTPM: 635.6

2169	Male, age 76, both hemispheres	863.5
2036	Male, age 80, both hemispheres	777.9
2746	Female, age 85, left hemisphere	660.4
2453	Male, age 74, right hemisphere	514.3
2320	Female, age 91, left hemisphere	361.6

Lateral parabrachial nucleus
nTPM: 545.6

2139	Female, age 85, right hemisphere	846.9
2013	Male, age 80, both hemispheres	535.4
2790	Male, age 61, both hemispheres	425.3
2792	Male, age 76, both hemispheres	374.9

Lateral vestibular nucleus
nTPM: 596.1

2184	Male, age 76, both hemispheres	697.6
2311	Male, age 80, both hemispheres	494.7

Locus coeruleus
nTPM: 626.9

2123	Female, age 91, both hemispheres	910.0
2014	Male, age 55, unknown	646.3
2720	Male, age 74, both hemispheres	596.5
2788	Male, age 74, unknown	584.5
2317	Female, age 72, unknown	579.3
1980	Male, age 76, both hemispheres	566.7
2162	Male, age 80, both hemispheres	504.9

Medial parabrachial nucleus
nTPM: 517.7

2854	Male, age 80, both hemispheres	623.8
2170	Female, age 91, both hemispheres	541.5
2786	Male, age 76, both hemispheres	492.5
2156	Male, age 61, both hemispheres	482.2
2463	Female, age 85, right hemisphere	448.3

Medial periolivary nuclei
nTPM: 611.1

2171	Female, age 85, both hemispheres	929.5
2063	Male, age 76, both hemispheres	855.9
2791	Male, age 74, right hemisphere	494.1
2081	Male, age 80, both hemispheres	426.7
2458	Female, age 91, both hemispheres	349.3

Motor facial nucleus
nTPM: 592.2

2062	Male, age 76, both hemispheres	903.1
2697	Female, age 85, both hemispheres	587.5
2365	Male, age 74, right hemisphere	573.9
2327	Male, age 80, both hemispheres	545.9
2795	Female, age 91, both hemispheres	517.4
2126	Male, age 61, both hemispheres	425.4

Motor trigeminal nucleus
nTPM: 485.7

2079	Male, age 80, both hemispheres	610.4
2309	Male, age 76, both hemispheres	510.7
2335	Male, age 61, both hemispheres	510.5
2560	Male, age 74, both hemispheres	443.8
2321	Female, age 91, both hemispheres	353.0

Nuclei of the trapezoid body
nTPM: 712.9

2159	Male, age 61, both hemispheres	936.1
2735	Female, age 85, both hemispheres	856.4
1983	Male, age 76, both hemispheres	813.6
2166	Male, age 80, both hemispheres	532.8
2368	Female, age 91, both hemispheres	425.5

Nucleus raphe magnus
nTPM: 725.3

2160	Male, age 61, both hemispheres	1120.0
2172	Female, age 85, both hemispheres	947.1
2455	Male, age 74, both hemispheres	660.2
2051	Male, age 76, both hemispheres	633.9
2328	Male, age 80, both hemispheres	581.9
2459	Female, age 91, both hemispheres	408.6

Paramedian reticular nucleus
nTPM: 617.8

2050	Female, age 85, both hemispheres	769.9
2057	Male, age 80, both hemispheres	667.0
2313	Male, age 61, both hemispheres	594.9
2052	Male, age 76, both hemispheres	439.5

Pedunculopontine tegmental nucleus
nTPM: 540.1

2338	Male, age 61, both hemispheres	555.1
1921	Female, age 85, both hemispheres	536.1
2334	Male, age 80, both hemispheres	529.1

Pontine nuclei
nTPM: 725.8

2787	Female, age 85, both hemispheres	1059.8
1863	Male, age 55, unknown	1016.1
2727	Male, age 61, right hemisphere	1011.8
1968	Male, age 76, left hemisphere	753.4
2109	Female, age 72, unknown	694.1
2115	Male, age 80, left hemisphere	505.2
2319	Female, age 91, both hemispheres	384.8
2454	Male, age 74, left hemisphere	380.9

Pontine raphe nucleus
nTPM: 650.8

2122	Female, age 85, midline	758.8
2853	Male, age 76, midline	542.7

Posteroventral cochlear nucleus
nTPM: 471.0

2752	Female, age 85, both hemispheres	670.1
2070	Male, age 76, both hemispheres	539.7
2371	Male, age 61, both hemispheres	471.3
2341	Male, age 80, both hemispheres	397.6
2135	Female, age 91, both hemispheres	276.2

Principal sensory trigeminal nucleus
nTPM: 659.0

2158	Male, age 61, both hemispheres	949.4
2008	Male, age 80, left hemisphere	703.4
2324	Male, age 76, both hemispheres	630.7
2367	Female, age 91, left hemisphere	352.5

Reticular pontine nucleus, caudal
nTPM: 517.4

2092	Male, age 76, both hemispheres	702.1
2332	Male, age 80, right hemisphere	638.6
2457	Female, age 91, both hemispheres	367.4
2559	Male, age 74, both hemispheres	361.4

Reticular pontine nucleus, oral
nTPM: 514.0

2012	Female, age 85, both hemispheres	686.6
1939	Male, age 80, both hemispheres	543.9
2167	Male, age 76, both hemispheres	530.6
2361	Male, age 74, both hemispheres	446.6
2366	Female, age 91, both hemispheres	362.3

Reticulotegmental nucleus
nTPM: 562.1

2325	Male, age 76, both hemispheres	705.8
2333	Male, age 80, both hemispheres	553.2
2452	Male, age 74, both hemispheres	501.6
2322	Female, age 91, both hemispheres	488.0

Spinal trigeminal nucleus, oral
nTPM: 549.5

2737	Female, age 85, both hemispheres	628.3
2164	Male, age 80, both hemispheres	587.2
1978	Male, age 76, both hemispheres	432.9

Subcoeruleus area
nTPM: 548.4

1958	Male, age 80, both hemispheres	614.7
2323	Female, age 91, left hemisphere	607.3
2089	Male, age 76, left hemisphere	567.6
2451	Male, age 74, both hemispheres	503.7
2369	Female, age 85, left hemisphere	448.6

Superior olive
nTPM: 588.8

1875	Female, age 85, both hemispheres	817.9
2020	Male, age 76, both hemispheres	609.5
2364	Male, age 74, right hemisphere	558.7
2329	Male, age 80, right hemisphere	519.2
2561	Female, age 91, both hemispheres	438.7

Ventral periolivary nuclei
nTPM: 663.2

2130	Female, age 85, both hemispheres	867.7
2165	Male, age 80, both hemispheres	764.5
2023	Male, age 76, both hemispheres	571.6
2794	Female, age 91, left hemisphere	448.9

Ventrolateral tegmental area, A5 NE cell group
nTPM: 541.0

2840	Female, age 85, both hemispheres	691.5
1959	Male, age 76, both hemispheres	613.8
2449	Male, age 74, both hemispheres	559.0
2161	Male, age 80, both hemispheres	532.3
2359	Male, age 61, both hemispheres	503.0
2456	Female, age 91, both hemispheres	346.3

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	1335.0

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 1114.4

FF:10182-103D2	60 years, female	1488.3
FF:10165-103B3	76 years, female	740.4

Pons
Scaled Tags Per Million: 1335.0

FF:10033-101E6

18-54 years, mixed

1335.0

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	502.8

Macaque sample

Sample description

nTPM

Pons
nTPM: 502.8

Samples: 2

Max nTPM: 543.6
Min nTPM: 461.9

Sample A		543.6
Sample B		461.9

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	712.5

Pig sample

Sample description

nTPM

Pons
nTPM: 712.5

Samples: 3

Max nTPM: 980.9
Min nTPM: 548.5

Sample A	Female	980.9
Sample B	Female	548.5
Sample C	Male	608.0

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	1000.5

Mouse sample

Sample description

nTPM

Pons
nTPM: 1000.5

Samples: 4

Max nTPM: 1052.1
Min nTPM: 949.1

Sample A		1052.1
Sample B		949.1
Sample C		1047.6
Sample D		953.1

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	0.0

Rat sample

Sample description

nTPM

Pons
nTPM: 0.0

Samples: 4

Max nTPM: 0.1
Min nTPM: 0.0

Sample A		0.0
Sample A		0.0
Sample A		0.1
Sample A		0.0