Brain tissue expression of DPYSL2 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	1173.7	nTPM
FANTOM5:	1249.2	Scaled Tags Per Million

Macaque:	517.4	nTPM
Mouse:	302.2	nTPM
Rat:	453.9	nTPM
Pig:	682.0	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	1173.7

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 974.2

2301	Female, age 85, both hemispheres	1119.6
2188	Female, age 91, both hemispheres	997.0
2090	Male, age 80, both hemispheres	980.2
1984	Male, age 76, both hemispheres	799.8

Dorsal cochlear nucleus
nTPM: 902.1

2058	Male, age 76, both hemispheres	941.0
2802	Male, age 74, right hemisphere	939.2
2187	Female, age 91, both hemispheres	930.5
2370	Male, age 61, both hemispheres	882.0
2378	Male, age 80, both hemispheres	817.8

Dorsal tegmental nucleus
nTPM: 898.2

2083	Male, age 80, both hemispheres	1029.6
2326	Male, age 74, both hemispheres	936.4
2358	Male, age 61, both hemispheres	837.3
1936	Male, age 76, left hemisphere	789.3

Dorsolateral tegmental area
nTPM: 850.0

2751	Female, age 85, both hemispheres	1016.1
2654	Male, age 80, both hemispheres	940.9
2337	Male, age 61, both hemispheres	777.5
2360	Male, age 74, both hemispheres	759.6
2141	Male, age 76, both hemispheres	756.0

Kolliker-Fuse nucleus
nTPM: 1007.8

2315	Male, age 76, right hemisphere	1035.8
2793	Female, age 91, left hemisphere	1030.8
2163	Male, age 80, both hemispheres	956.9

Lateral lemniscal nuclei
nTPM: 1047.1

2169	Male, age 76, both hemispheres	1121.1
2746	Female, age 85, left hemisphere	1098.1
2036	Male, age 80, both hemispheres	1046.5
2453	Male, age 74, right hemisphere	993.7
2320	Female, age 91, left hemisphere	975.9

Lateral parabrachial nucleus
nTPM: 1044.2

2792	Male, age 76, both hemispheres	1149.8
2139	Female, age 85, right hemisphere	1141.6
2013	Male, age 80, both hemispheres	1033.3
2790	Male, age 61, both hemispheres	852.2

Lateral vestibular nucleus
nTPM: 958.6

2311	Male, age 80, both hemispheres	990.2
2184	Male, age 76, both hemispheres	927.0

Locus coeruleus
nTPM: 857.0

2014	Male, age 55, unknown	1014.7
2317	Female, age 72, unknown	882.0
2123	Female, age 91, both hemispheres	876.2
2162	Male, age 80, both hemispheres	851.0
1980	Male, age 76, both hemispheres	835.9
2788	Male, age 74, unknown	778.2
2720	Male, age 74, both hemispheres	760.6

Medial parabrachial nucleus
nTPM: 939.6

2170	Female, age 91, both hemispheres	988.7
2463	Female, age 85, right hemisphere	979.7
2156	Male, age 61, both hemispheres	958.8
2854	Male, age 80, both hemispheres	899.0
2786	Male, age 76, both hemispheres	871.6

Medial periolivary nuclei
nTPM: 1026.4

2063	Male, age 76, both hemispheres	1210.2
2791	Male, age 74, right hemisphere	1125.5
2171	Female, age 85, both hemispheres	1022.2
2081	Male, age 80, both hemispheres	935.6
2458	Female, age 91, both hemispheres	838.7

Motor facial nucleus
nTPM: 1030.0

2365	Male, age 74, right hemisphere	1244.8
2062	Male, age 76, both hemispheres	1207.7
2126	Male, age 61, both hemispheres	969.3
2697	Female, age 85, both hemispheres	950.2
2327	Male, age 80, both hemispheres	948.5
2795	Female, age 91, both hemispheres	859.6

Motor trigeminal nucleus
nTPM: 946.0

2560	Male, age 74, both hemispheres	1040.4
2079	Male, age 80, both hemispheres	1013.9
2335	Male, age 61, both hemispheres	935.3
2309	Male, age 76, both hemispheres	898.1
2321	Female, age 91, both hemispheres	842.3

Nuclei of the trapezoid body
nTPM: 1045.3

2159	Male, age 61, both hemispheres	1168.5
1983	Male, age 76, both hemispheres	1163.9
2735	Female, age 85, both hemispheres	1058.5
2166	Male, age 80, both hemispheres	945.8
2368	Female, age 91, both hemispheres	889.7

Nucleus raphe magnus
nTPM: 1064.8

2160	Male, age 61, both hemispheres	1303.0
2455	Male, age 74, both hemispheres	1120.9
2172	Female, age 85, both hemispheres	1042.9
2051	Male, age 76, both hemispheres	1005.2
2328	Male, age 80, both hemispheres	987.5
2459	Female, age 91, both hemispheres	929.3

Paramedian reticular nucleus
nTPM: 966.3

2057	Male, age 80, both hemispheres	1059.8
2050	Female, age 85, both hemispheres	1052.0
2313	Male, age 61, both hemispheres	946.3
2052	Male, age 76, both hemispheres	807.1

Pedunculopontine tegmental nucleus
nTPM: 850.9

2334	Male, age 80, both hemispheres	885.1
2338	Male, age 61, both hemispheres	840.5
1921	Female, age 85, both hemispheres	827.1

Pontine nuclei
nTPM: 1173.7

1863	Male, age 55, unknown	1304.2
2454	Male, age 74, left hemisphere	1279.8
2787	Female, age 85, both hemispheres	1261.2
2109	Female, age 72, unknown	1248.6
2727	Male, age 61, right hemisphere	1211.9
1968	Male, age 76, left hemisphere	1184.3
2319	Female, age 91, both hemispheres	982.6
2115	Male, age 80, left hemisphere	917.3

Pontine raphe nucleus
nTPM: 916.4

2122	Female, age 85, midline	1024.6
2853	Male, age 76, midline	808.2

Posteroventral cochlear nucleus
nTPM: 954.4

2135	Female, age 91, both hemispheres	1019.9
2070	Male, age 76, both hemispheres	972.0
2752	Female, age 85, both hemispheres	957.0
2341	Male, age 80, both hemispheres	915.0
2371	Male, age 61, both hemispheres	908.2

Principal sensory trigeminal nucleus
nTPM: 1011.5

2158	Male, age 61, both hemispheres	1190.5
2008	Male, age 80, left hemisphere	980.6
2367	Female, age 91, left hemisphere	960.1
2324	Male, age 76, both hemispheres	914.7

Reticular pontine nucleus, caudal
nTPM: 1041.0

2092	Male, age 76, both hemispheres	1178.7
2559	Male, age 74, both hemispheres	1027.3
2332	Male, age 80, right hemisphere	987.3
2457	Female, age 91, both hemispheres	970.5

Reticular pontine nucleus, oral
nTPM: 1007.2

2361	Male, age 74, both hemispheres	1179.4
2012	Female, age 85, both hemispheres	1049.7
2366	Female, age 91, both hemispheres	1023.3
1939	Male, age 80, both hemispheres	913.0
2167	Male, age 76, both hemispheres	870.6

Reticulotegmental nucleus
nTPM: 900.9

2452	Male, age 74, both hemispheres	928.4
2325	Male, age 76, both hemispheres	905.1
2333	Male, age 80, both hemispheres	893.1
2322	Female, age 91, both hemispheres	877.2

Spinal trigeminal nucleus, oral
nTPM: 871.7

2164	Male, age 80, both hemispheres	900.2
1978	Male, age 76, both hemispheres	875.5
2737	Female, age 85, both hemispheres	839.4

Subcoeruleus area
nTPM: 902.7

2369	Female, age 85, left hemisphere	1034.1
2089	Male, age 76, left hemisphere	991.0
1958	Male, age 80, both hemispheres	925.2
2323	Female, age 91, left hemisphere	804.5
2451	Male, age 74, both hemispheres	758.8

Superior olive
nTPM: 1045.0

2364	Male, age 74, right hemisphere	1207.9
2020	Male, age 76, both hemispheres	1125.7
1875	Female, age 85, both hemispheres	1078.3
2329	Male, age 80, right hemisphere	982.6
2561	Female, age 91, both hemispheres	830.2

Ventral periolivary nuclei
nTPM: 1030.8

2023	Male, age 76, both hemispheres	1184.5
2130	Female, age 85, both hemispheres	1141.9
2165	Male, age 80, both hemispheres	1045.6
2794	Female, age 91, left hemisphere	751.4

Ventrolateral tegmental area, A5 NE cell group
nTPM: 961.9

1959	Male, age 76, both hemispheres	1066.9
2449	Male, age 74, both hemispheres	1053.1
2840	Female, age 85, both hemispheres	963.1
2161	Male, age 80, both hemispheres	920.4
2456	Female, age 91, both hemispheres	887.9
2359	Male, age 61, both hemispheres	880.3

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	1249.2

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 1249.2

FF:10182-103D2	60 years, female	1526.1
FF:10165-103B3	76 years, female	972.3

Pons
Scaled Tags Per Million: 872.2

FF:10033-101E6

18-54 years, mixed

872.2

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	517.4

Macaque sample

Sample description

nTPM

Pons
nTPM: 517.4

Samples: 2

Max nTPM: 596.2
Min nTPM: 438.5

Sample A		596.2
Sample B		438.5

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	682.0

Pig sample

Sample description

nTPM

Pons
nTPM: 682.0

Samples: 3

Max nTPM: 736.4
Min nTPM: 617.0

Sample A	Female	736.4
Sample B	Female	617.0
Sample C	Male	692.7

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	302.2

Mouse sample

Sample description

nTPM

Pons
nTPM: 302.2

Samples: 4

Max nTPM: 320.3
Min nTPM: 287.4

Sample A		320.3
Sample B		287.4
Sample C		311.1
Sample D		289.9

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	453.9

Rat sample

Sample description

nTPM

Pons
nTPM: 454.0

Samples: 4

Max nTPM: 467.7
Min nTPM: 436.6

Sample A		436.6
Sample A		455.0
Sample A		456.5
Sample A		467.7