Brain tissue expression of RPL34 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	345.6	nTPM
FANTOM5:	28.1	Scaled Tags Per Million

Macaque:	10.6	nTPM
Mouse:	173.7	nTPM
Rat:	140.0	nTPM
Pig:	620.5	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	345.6

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 310.7

2188	Female, age 91, both hemispheres	383.3
2090	Male, age 80, both hemispheres	334.6
1984	Male, age 76, both hemispheres	262.8
2301	Female, age 85, both hemispheres	262.2

Dorsal cochlear nucleus
nTPM: 314.2

2802	Male, age 74, right hemisphere	367.7
2187	Female, age 91, both hemispheres	341.0
2378	Male, age 80, both hemispheres	315.4
2370	Male, age 61, both hemispheres	298.4
2058	Male, age 76, both hemispheres	248.7

Dorsal tegmental nucleus
nTPM: 292.9

2326	Male, age 74, both hemispheres	378.3
2083	Male, age 80, both hemispheres	297.0
1936	Male, age 76, left hemisphere	277.3
2358	Male, age 61, both hemispheres	218.9

Dorsolateral tegmental area
nTPM: 297.0

2654	Male, age 80, both hemispheres	346.8
2751	Female, age 85, both hemispheres	334.7
2360	Male, age 74, both hemispheres	327.1
2337	Male, age 61, both hemispheres	254.6
2141	Male, age 76, both hemispheres	222.0

Kolliker-Fuse nucleus
nTPM: 290.5

2315	Male, age 76, right hemisphere	327.2
2793	Female, age 91, left hemisphere	282.0
2163	Male, age 80, both hemispheres	262.2

Lateral lemniscal nuclei
nTPM: 251.3

2746	Female, age 85, left hemisphere	271.9
2169	Male, age 76, both hemispheres	263.5
2453	Male, age 74, right hemisphere	254.1
2036	Male, age 80, both hemispheres	237.6
2320	Female, age 91, left hemisphere	229.4

Lateral parabrachial nucleus
nTPM: 296.7

2792	Male, age 76, both hemispheres	354.1
2013	Male, age 80, both hemispheres	331.4
2139	Female, age 85, right hemisphere	276.2
2790	Male, age 61, both hemispheres	225.1

Lateral vestibular nucleus
nTPM: 258.8

2311	Male, age 80, both hemispheres	301.7
2184	Male, age 76, both hemispheres	215.9

Locus coeruleus
nTPM: 244.5

2720	Male, age 74, both hemispheres	277.6
2788	Male, age 74, unknown	256.1
2123	Female, age 91, both hemispheres	253.7
2162	Male, age 80, both hemispheres	246.0
2014	Male, age 55, unknown	237.9
2317	Female, age 72, unknown	231.2
1980	Male, age 76, both hemispheres	209.2

Medial parabrachial nucleus
nTPM: 283.6

2170	Female, age 91, both hemispheres	367.9
2463	Female, age 85, right hemisphere	294.8
2854	Male, age 80, both hemispheres	276.6
2786	Male, age 76, both hemispheres	255.4
2156	Male, age 61, both hemispheres	223.2

Medial periolivary nuclei
nTPM: 287.0

2063	Male, age 76, both hemispheres	355.2
2081	Male, age 80, both hemispheres	289.0
2791	Male, age 74, right hemisphere	283.3
2458	Female, age 91, both hemispheres	271.7
2171	Female, age 85, both hemispheres	235.9

Motor facial nucleus
nTPM: 269.6

2062	Male, age 76, both hemispheres	319.0
2126	Male, age 61, both hemispheres	300.6
2365	Male, age 74, right hemisphere	273.6
2795	Female, age 91, both hemispheres	273.1
2697	Female, age 85, both hemispheres	260.1
2327	Male, age 80, both hemispheres	191.4

Motor trigeminal nucleus
nTPM: 262.1

2321	Female, age 91, both hemispheres	275.8
2560	Male, age 74, both hemispheres	274.1
2309	Male, age 76, both hemispheres	267.7
2079	Male, age 80, both hemispheres	248.3
2335	Male, age 61, both hemispheres	244.9

Nuclei of the trapezoid body
nTPM: 285.7

1983	Male, age 76, both hemispheres	365.3
2159	Male, age 61, both hemispheres	275.4
2368	Female, age 91, both hemispheres	267.7
2735	Female, age 85, both hemispheres	266.2
2166	Male, age 80, both hemispheres	254.0

Nucleus raphe magnus
nTPM: 246.2

2051	Male, age 76, both hemispheres	265.0
2160	Male, age 61, both hemispheres	260.2
2455	Male, age 74, both hemispheres	258.6
2459	Female, age 91, both hemispheres	256.7
2328	Male, age 80, both hemispheres	219.5
2172	Female, age 85, both hemispheres	217.4

Paramedian reticular nucleus
nTPM: 302.1

2052	Male, age 76, both hemispheres	335.4
2057	Male, age 80, both hemispheres	304.6
2313	Male, age 61, both hemispheres	294.4
2050	Female, age 85, both hemispheres	273.9

Pedunculopontine tegmental nucleus
nTPM: 268.9

2334	Male, age 80, both hemispheres	289.9
2338	Male, age 61, both hemispheres	263.2
1921	Female, age 85, both hemispheres	253.6

Pontine nuclei
nTPM: 291.1

2319	Female, age 91, both hemispheres	349.7
1968	Male, age 76, left hemisphere	321.7
2454	Male, age 74, left hemisphere	304.7
2727	Male, age 61, right hemisphere	295.5
1863	Male, age 55, unknown	293.1
2109	Female, age 72, unknown	268.3
2115	Male, age 80, left hemisphere	261.3
2787	Female, age 85, both hemispheres	234.2

Pontine raphe nucleus
nTPM: 270.2

2122	Female, age 85, midline	277.0
2853	Male, age 76, midline	263.4

Posteroventral cochlear nucleus
nTPM: 345.6

2135	Female, age 91, both hemispheres	438.8
2341	Male, age 80, both hemispheres	407.9
2371	Male, age 61, both hemispheres	341.7
2752	Female, age 85, both hemispheres	303.2
2070	Male, age 76, both hemispheres	236.5

Principal sensory trigeminal nucleus
nTPM: 246.3

2158	Male, age 61, both hemispheres	269.7
2367	Female, age 91, left hemisphere	259.1
2008	Male, age 80, left hemisphere	246.4
2324	Male, age 76, both hemispheres	209.9

Reticular pontine nucleus, caudal
nTPM: 292.0

2559	Male, age 74, both hemispheres	354.7
2457	Female, age 91, both hemispheres	315.2
2092	Male, age 76, both hemispheres	308.1
2332	Male, age 80, right hemisphere	189.8

Reticular pontine nucleus, oral
nTPM: 296.7

2366	Female, age 91, both hemispheres	340.9
2361	Male, age 74, both hemispheres	311.3
1939	Male, age 80, both hemispheres	306.4
2167	Male, age 76, both hemispheres	264.2
2012	Female, age 85, both hemispheres	260.6

Reticulotegmental nucleus
nTPM: 263.3

2452	Male, age 74, both hemispheres	333.6
2322	Female, age 91, both hemispheres	261.6
2325	Male, age 76, both hemispheres	231.9
2333	Male, age 80, both hemispheres	226.0

Spinal trigeminal nucleus, oral
nTPM: 254.3

2737	Female, age 85, both hemispheres	255.6
1978	Male, age 76, both hemispheres	253.9
2164	Male, age 80, both hemispheres	253.5

Subcoeruleus area
nTPM: 298.9

2451	Male, age 74, both hemispheres	376.8
2369	Female, age 85, left hemisphere	340.3
2089	Male, age 76, left hemisphere	269.4
1958	Male, age 80, both hemispheres	266.3
2323	Female, age 91, left hemisphere	241.8

Superior olive
nTPM: 277.5

2020	Male, age 76, both hemispheres	366.9
2364	Male, age 74, right hemisphere	284.3
1875	Female, age 85, both hemispheres	275.3
2561	Female, age 91, both hemispheres	257.6
2329	Male, age 80, right hemisphere	203.5

Ventral periolivary nuclei
nTPM: 287.5

2023	Male, age 76, both hemispheres	363.3
2794	Female, age 91, left hemisphere	285.4
2165	Male, age 80, both hemispheres	265.3
2130	Female, age 85, both hemispheres	235.9

Ventrolateral tegmental area, A5 NE cell group
nTPM: 256.9

1959	Male, age 76, both hemispheres	291.7
2456	Female, age 91, both hemispheres	277.7
2161	Male, age 80, both hemispheres	266.4
2359	Male, age 61, both hemispheres	237.0
2449	Male, age 74, both hemispheres	234.4
2840	Female, age 85, both hemispheres	234.1

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	28.1

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 28.1

FF:10165-103B3	76 years, female	29.0
FF:10182-103D2	60 years, female	27.2

Pons
Scaled Tags Per Million: 22.3

FF:10033-101E6

18-54 years, mixed

22.3

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	10.6

Macaque sample

Sample description

nTPM

Pons
nTPM: 10.6

Samples: 2

Max nTPM: 13.1
Min nTPM: 8.2

Sample A		13.1
Sample B		8.2

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	620.5

Pig sample

Sample description

nTPM

Pons
nTPM: 620.5

Samples: 3

Max nTPM: 763.0
Min nTPM: 479.7

Sample A	Female	618.8
Sample B	Female	479.7
Sample C	Male	763.0

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	173.7

Mouse sample

Sample description

nTPM

Pons
nTPM: 173.8

Samples: 4

Max nTPM: 187.8
Min nTPM: 147.0

Sample A		147.0
Sample B		187.8
Sample C		184.6
Sample D		175.7

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	140.0

Rat sample

Sample description

nTPM

Pons
nTPM: 140.1

Samples: 4

Max nTPM: 149.5
Min nTPM: 128.0

Sample A		128.0
Sample A		149.5
Sample A		141.5
Sample A		141.2