Brain tissue expression of RPS12 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	435.0	nTPM
FANTOM5:	404.5	Scaled Tags Per Million

Macaque:	272.7	nTPM
Mouse:	183.3	nTPM
Rat:	0.8	nTPM
Pig:	444.1	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	435.0

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 403.5

2188	Female, age 91, both hemispheres	501.5
2090	Male, age 80, both hemispheres	475.6
2301	Female, age 85, both hemispheres	336.5
1984	Male, age 76, both hemispheres	300.5

Dorsal cochlear nucleus
nTPM: 432.5

2802	Male, age 74, right hemisphere	508.1
2187	Female, age 91, both hemispheres	463.9
2370	Male, age 61, both hemispheres	455.8
2378	Male, age 80, both hemispheres	447.6
2058	Male, age 76, both hemispheres	287.0

Dorsal tegmental nucleus
nTPM: 402.5

2326	Male, age 74, both hemispheres	459.2
2083	Male, age 80, both hemispheres	450.9
2358	Male, age 61, both hemispheres	380.0
1936	Male, age 76, left hemisphere	319.9

Dorsolateral tegmental area
nTPM: 388.5

2654	Male, age 80, both hemispheres	479.7
2337	Male, age 61, both hemispheres	411.1
2751	Female, age 85, both hemispheres	404.4
2360	Male, age 74, both hemispheres	374.8
2141	Male, age 76, both hemispheres	272.4

Kolliker-Fuse nucleus
nTPM: 386.5

2315	Male, age 76, right hemisphere	412.1
2793	Female, age 91, left hemisphere	393.1
2163	Male, age 80, both hemispheres	354.4

Lateral lemniscal nuclei
nTPM: 287.1

2453	Male, age 74, right hemisphere	318.9
2320	Female, age 91, left hemisphere	291.9
2746	Female, age 85, left hemisphere	288.9
2169	Male, age 76, both hemispheres	282.8
2036	Male, age 80, both hemispheres	252.8

Lateral parabrachial nucleus
nTPM: 394.3

2792	Male, age 76, both hemispheres	488.1
2013	Male, age 80, both hemispheres	428.7
2790	Male, age 61, both hemispheres	334.5
2139	Female, age 85, right hemisphere	325.8

Lateral vestibular nucleus
nTPM: 345.8

2311	Male, age 80, both hemispheres	420.9
2184	Male, age 76, both hemispheres	270.8

Locus coeruleus
nTPM: 298.2

2720	Male, age 74, both hemispheres	347.8
2162	Male, age 80, both hemispheres	337.4
2123	Female, age 91, both hemispheres	316.7
2317	Female, age 72, unknown	309.6
2014	Male, age 55, unknown	282.8
1980	Male, age 76, both hemispheres	251.1
2788	Male, age 74, unknown	242.0

Medial parabrachial nucleus
nTPM: 375.6

2170	Female, age 91, both hemispheres	541.8
2854	Male, age 80, both hemispheres	363.6
2463	Female, age 85, right hemisphere	355.3
2156	Male, age 61, both hemispheres	321.7
2786	Male, age 76, both hemispheres	295.6

Medial periolivary nuclei
nTPM: 310.0

2458	Female, age 91, both hemispheres	348.0
2081	Male, age 80, both hemispheres	347.7
2791	Male, age 74, right hemisphere	314.6
2063	Male, age 76, both hemispheres	310.6
2171	Female, age 85, both hemispheres	228.8

Motor facial nucleus
nTPM: 308.4

2795	Female, age 91, both hemispheres	357.7
2126	Male, age 61, both hemispheres	356.8
2365	Male, age 74, right hemisphere	335.4
2697	Female, age 85, both hemispheres	324.1
2062	Male, age 76, both hemispheres	249.7
2327	Male, age 80, both hemispheres	226.4

Motor trigeminal nucleus
nTPM: 345.5

2560	Male, age 74, both hemispheres	388.6
2321	Female, age 91, both hemispheres	383.4
2335	Male, age 61, both hemispheres	367.6
2309	Male, age 76, both hemispheres	315.0
2079	Male, age 80, both hemispheres	272.8

Nuclei of the trapezoid body
nTPM: 293.3

2166	Male, age 80, both hemispheres	340.8
1983	Male, age 76, both hemispheres	326.0
2368	Female, age 91, both hemispheres	323.8
2159	Male, age 61, both hemispheres	276.6
2735	Female, age 85, both hemispheres	199.2

Nucleus raphe magnus
nTPM: 283.8

2459	Female, age 91, both hemispheres	339.6
2051	Male, age 76, both hemispheres	308.2
2328	Male, age 80, both hemispheres	299.5
2455	Male, age 74, both hemispheres	279.0
2160	Male, age 61, both hemispheres	248.5
2172	Female, age 85, both hemispheres	227.8

Paramedian reticular nucleus
nTPM: 358.4

2052	Male, age 76, both hemispheres	416.3
2313	Male, age 61, both hemispheres	345.7
2057	Male, age 80, both hemispheres	343.0
2050	Female, age 85, both hemispheres	328.6

Pedunculopontine tegmental nucleus
nTPM: 352.5

2334	Male, age 80, both hemispheres	404.9
2338	Male, age 61, both hemispheres	387.3
1921	Female, age 85, both hemispheres	265.4

Pontine nuclei
nTPM: 334.8

2319	Female, age 91, both hemispheres	421.9
2454	Male, age 74, left hemisphere	376.7
1863	Male, age 55, unknown	342.1
2115	Male, age 80, left hemisphere	338.1
2787	Female, age 85, both hemispheres	326.2
2109	Female, age 72, unknown	315.1
1968	Male, age 76, left hemisphere	298.6
2727	Male, age 61, right hemisphere	259.5

Pontine raphe nucleus
nTPM: 295.6

2853	Male, age 76, midline	296.6
2122	Female, age 85, midline	294.5

Posteroventral cochlear nucleus
nTPM: 435.0

2341	Male, age 80, both hemispheres	577.4
2135	Female, age 91, both hemispheres	494.5
2371	Male, age 61, both hemispheres	471.7
2752	Female, age 85, both hemispheres	316.7
2070	Male, age 76, both hemispheres	314.7

Principal sensory trigeminal nucleus
nTPM: 289.4

2367	Female, age 91, left hemisphere	380.2
2158	Male, age 61, both hemispheres	278.8
2324	Male, age 76, both hemispheres	257.5
2008	Male, age 80, left hemisphere	241.0

Reticular pontine nucleus, caudal
nTPM: 363.9

2559	Male, age 74, both hemispheres	450.2
2457	Female, age 91, both hemispheres	401.1
2092	Male, age 76, both hemispheres	363.0
2332	Male, age 80, right hemisphere	241.4

Reticular pontine nucleus, oral
nTPM: 389.0

2366	Female, age 91, both hemispheres	474.1
2361	Male, age 74, both hemispheres	430.3
1939	Male, age 80, both hemispheres	395.6
2167	Male, age 76, both hemispheres	339.9
2012	Female, age 85, both hemispheres	305.2

Reticulotegmental nucleus
nTPM: 358.0

2452	Male, age 74, both hemispheres	453.8
2322	Female, age 91, both hemispheres	376.0
2333	Male, age 80, both hemispheres	328.1
2325	Male, age 76, both hemispheres	274.2

Spinal trigeminal nucleus, oral
nTPM: 305.9

2164	Male, age 80, both hemispheres	352.1
1978	Male, age 76, both hemispheres	298.2
2737	Female, age 85, both hemispheres	267.4

Subcoeruleus area
nTPM: 362.8

2451	Male, age 74, both hemispheres	485.9
2369	Female, age 85, left hemisphere	436.6
1958	Male, age 80, both hemispheres	338.0
2323	Female, age 91, left hemisphere	291.4
2089	Male, age 76, left hemisphere	262.2

Superior olive
nTPM: 327.6

2561	Female, age 91, both hemispheres	385.7
2020	Male, age 76, both hemispheres	366.0
2364	Male, age 74, right hemisphere	340.6
1875	Female, age 85, both hemispheres	273.0
2329	Male, age 80, right hemisphere	273.0

Ventral periolivary nuclei
nTPM: 303.8

2023	Male, age 76, both hemispheres	383.8
2794	Female, age 91, left hemisphere	355.8
2165	Male, age 80, both hemispheres	306.2
2130	Female, age 85, both hemispheres	169.3

Ventrolateral tegmental area, A5 NE cell group
nTPM: 327.0

2359	Male, age 61, both hemispheres	365.0
2161	Male, age 80, both hemispheres	347.3
2456	Female, age 91, both hemispheres	328.5
2840	Female, age 85, both hemispheres	318.5
2449	Male, age 74, both hemispheres	301.7
1959	Male, age 76, both hemispheres	301.3

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	404.5

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 404.5

FF:10182-103D2	60 years, female	439.6
FF:10165-103B3	76 years, female	369.4

Pons
Scaled Tags Per Million: 212.9

FF:10033-101E6

18-54 years, mixed

212.9

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	272.7

Macaque sample

Sample description

nTPM

Pons
nTPM: 272.8

Samples: 2

Max nTPM: 313.6
Min nTPM: 231.9

Sample A		231.9
Sample B		313.6

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	444.1

Pig sample

Sample description

nTPM

Pons
nTPM: 444.1

Samples: 3

Max nTPM: 607.8
Min nTPM: 349.7

Sample A	Female	374.9
Sample B	Female	349.7
Sample C	Male	607.8

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	183.3

Mouse sample

Sample description

nTPM

Pons
nTPM: 183.3

Samples: 4

Max nTPM: 212.9
Min nTPM: 140.0

Sample A		140.0
Sample B		212.9
Sample C		190.6
Sample D		189.8

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	0.8

Rat sample

Sample description

nTPM

Pons
nTPM: 0.8

Samples: 4

Max nTPM: 1.9
Min nTPM: 0.0

Sample A		1.9
Sample A		0.0
Sample A		1.4
Sample A		0.0