Brain tissue expression of RPL7 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	456.9	nTPM
FANTOM5:	3.7	Scaled Tags Per Million

Mouse:	155.8	nTPM
Rat:	13.6	nTPM
Pig:	526.4	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	456.9

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 446.0

2090	Male, age 80, both hemispheres	503.3
2188	Female, age 91, both hemispheres	457.2
2301	Female, age 85, both hemispheres	421.3
1984	Male, age 76, both hemispheres	402.1

Dorsal cochlear nucleus
nTPM: 449.9

2802	Male, age 74, right hemisphere	511.3
2378	Male, age 80, both hemispheres	476.4
2187	Female, age 91, both hemispheres	475.1
2370	Male, age 61, both hemispheres	412.6
2058	Male, age 76, both hemispheres	374.2

Dorsal tegmental nucleus
nTPM: 419.0

2326	Male, age 74, both hemispheres	478.2
2083	Male, age 80, both hemispheres	475.5
2358	Male, age 61, both hemispheres	364.4
1936	Male, age 76, left hemisphere	358.1

Dorsolateral tegmental area
nTPM: 434.4

2654	Male, age 80, both hemispheres	507.9
2337	Male, age 61, both hemispheres	469.0
2360	Male, age 74, both hemispheres	421.0
2751	Female, age 85, both hemispheres	416.0
2141	Male, age 76, both hemispheres	358.3

Kolliker-Fuse nucleus
nTPM: 428.5

2315	Male, age 76, right hemisphere	482.2
2163	Male, age 80, both hemispheres	404.8
2793	Female, age 91, left hemisphere	398.4

Lateral lemniscal nuclei
nTPM: 355.5

2169	Male, age 76, both hemispheres	453.3
2746	Female, age 85, left hemisphere	388.5
2320	Female, age 91, left hemisphere	341.4
2453	Male, age 74, right hemisphere	324.2
2036	Male, age 80, both hemispheres	270.2

Lateral parabrachial nucleus
nTPM: 442.6

2792	Male, age 76, both hemispheres	520.8
2139	Female, age 85, right hemisphere	462.3
2013	Male, age 80, both hemispheres	455.1
2790	Male, age 61, both hemispheres	331.9

Lateral vestibular nucleus
nTPM: 385.2

2311	Male, age 80, both hemispheres	449.0
2184	Male, age 76, both hemispheres	321.5

Locus coeruleus
nTPM: 357.2

2720	Male, age 74, both hemispheres	387.9
2123	Female, age 91, both hemispheres	383.3
2162	Male, age 80, both hemispheres	371.7
2014	Male, age 55, unknown	370.8
2317	Female, age 72, unknown	354.5
2788	Male, age 74, unknown	349.1
1980	Male, age 76, both hemispheres	283.1

Medial parabrachial nucleus
nTPM: 406.1

2170	Female, age 91, both hemispheres	503.4
2854	Male, age 80, both hemispheres	451.9
2463	Female, age 85, right hemisphere	394.6
2786	Male, age 76, both hemispheres	362.0
2156	Male, age 61, both hemispheres	318.7

Medial periolivary nuclei
nTPM: 424.2

2063	Male, age 76, both hemispheres	538.4
2081	Male, age 80, both hemispheres	416.5
2791	Male, age 74, right hemisphere	400.1
2171	Female, age 85, both hemispheres	393.9
2458	Female, age 91, both hemispheres	372.0

Motor facial nucleus
nTPM: 397.3

2062	Male, age 76, both hemispheres	490.9
2126	Male, age 61, both hemispheres	420.7
2697	Female, age 85, both hemispheres	393.5
2795	Female, age 91, both hemispheres	385.2
2365	Male, age 74, right hemisphere	380.6
2327	Male, age 80, both hemispheres	312.8

Motor trigeminal nucleus
nTPM: 372.0

2309	Male, age 76, both hemispheres	389.8
2321	Female, age 91, both hemispheres	386.0
2560	Male, age 74, both hemispheres	385.3
2335	Male, age 61, both hemispheres	356.6
2079	Male, age 80, both hemispheres	342.4

Nuclei of the trapezoid body
nTPM: 420.9

1983	Male, age 76, both hemispheres	559.7
2159	Male, age 61, both hemispheres	414.0
2166	Male, age 80, both hemispheres	392.3
2735	Female, age 85, both hemispheres	385.8
2368	Female, age 91, both hemispheres	352.5

Nucleus raphe magnus
nTPM: 380.2

2051	Male, age 76, both hemispheres	420.8
2160	Male, age 61, both hemispheres	393.1
2459	Female, age 91, both hemispheres	381.8
2172	Female, age 85, both hemispheres	366.5
2455	Male, age 74, both hemispheres	361.9
2328	Male, age 80, both hemispheres	357.2

Paramedian reticular nucleus
nTPM: 412.7

2057	Male, age 80, both hemispheres	419.1
2052	Male, age 76, both hemispheres	413.9
2050	Female, age 85, both hemispheres	411.3
2313	Male, age 61, both hemispheres	406.6

Pedunculopontine tegmental nucleus
nTPM: 417.3

2338	Male, age 61, both hemispheres	478.6
2334	Male, age 80, both hemispheres	433.9
1921	Female, age 85, both hemispheres	339.4

Pontine nuclei
nTPM: 411.5

1863	Male, age 55, unknown	452.2
1968	Male, age 76, left hemisphere	439.6
2319	Female, age 91, both hemispheres	422.6
2727	Male, age 61, right hemisphere	407.6
2109	Female, age 72, unknown	396.0
2787	Female, age 85, both hemispheres	393.4
2454	Male, age 74, left hemisphere	392.1
2115	Male, age 80, left hemisphere	388.8

Pontine raphe nucleus
nTPM: 396.9

2122	Female, age 85, midline	416.1
2853	Male, age 76, midline	377.8

Posteroventral cochlear nucleus
nTPM: 456.9

2341	Male, age 80, both hemispheres	539.3
2135	Female, age 91, both hemispheres	486.6
2371	Male, age 61, both hemispheres	462.8
2752	Female, age 85, both hemispheres	435.1
2070	Male, age 76, both hemispheres	360.5

Principal sensory trigeminal nucleus
nTPM: 365.1

2158	Male, age 61, both hemispheres	384.7
2367	Female, age 91, left hemisphere	368.4
2324	Male, age 76, both hemispheres	363.6
2008	Male, age 80, left hemisphere	343.7

Reticular pontine nucleus, caudal
nTPM: 402.4

2092	Male, age 76, both hemispheres	478.1
2559	Male, age 74, both hemispheres	447.6
2457	Female, age 91, both hemispheres	398.7
2332	Male, age 80, right hemisphere	285.0

Reticular pontine nucleus, oral
nTPM: 397.7

1939	Male, age 80, both hemispheres	447.7
2167	Male, age 76, both hemispheres	401.8
2366	Female, age 91, both hemispheres	398.0
2012	Female, age 85, both hemispheres	379.4
2361	Male, age 74, both hemispheres	361.8

Reticulotegmental nucleus
nTPM: 394.5

2322	Female, age 91, both hemispheres	441.5
2452	Male, age 74, both hemispheres	408.7
2325	Male, age 76, both hemispheres	372.0
2333	Male, age 80, both hemispheres	355.7

Spinal trigeminal nucleus, oral
nTPM: 352.0

1978	Male, age 76, both hemispheres	359.8
2164	Male, age 80, both hemispheres	350.6
2737	Female, age 85, both hemispheres	345.6

Subcoeruleus area
nTPM: 410.2

2451	Male, age 74, both hemispheres	457.8
1958	Male, age 80, both hemispheres	422.1
2369	Female, age 85, left hemisphere	415.4
2089	Male, age 76, left hemisphere	385.0
2323	Female, age 91, left hemisphere	370.4

Superior olive
nTPM: 405.1

2020	Male, age 76, both hemispheres	496.5
1875	Female, age 85, both hemispheres	414.5
2364	Male, age 74, right hemisphere	399.6
2561	Female, age 91, both hemispheres	359.8
2329	Male, age 80, right hemisphere	354.9

Ventral periolivary nuclei
nTPM: 415.8

2023	Male, age 76, both hemispheres	504.0
2130	Female, age 85, both hemispheres	399.5
2165	Male, age 80, both hemispheres	381.1
2794	Female, age 91, left hemisphere	378.5

Ventrolateral tegmental area, A5 NE cell group
nTPM: 382.3

1959	Male, age 76, both hemispheres	449.6
2161	Male, age 80, both hemispheres	394.0
2840	Female, age 85, both hemispheres	392.5
2359	Male, age 61, both hemispheres	368.8
2456	Female, age 91, both hemispheres	358.0
2449	Male, age 74, both hemispheres	331.0

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	3.7

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 3.7

FF:10165-103B3	76 years, female	3.9
FF:10182-103D2	60 years, female	3.5

Pons
Scaled Tags Per Million: 2.4

FF:10033-101E6

18-54 years, mixed

2.4

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	526.4

Pig sample

Sample description

nTPM

Pons
nTPM: 526.4

Samples: 3

Max nTPM: 673.2
Min nTPM: 403.0

Sample A	Female	502.9
Sample B	Female	403.0
Sample C	Male	673.2

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	155.8

Mouse sample

Sample description

nTPM

Pons
nTPM: 155.8

Samples: 4

Max nTPM: 163.8
Min nTPM: 137.7

Sample A		137.7
Sample B		163.8
Sample C		161.1
Sample D		160.6

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	13.6

Rat sample

Sample description

nTPM

Pons
nTPM: 13.6

Samples: 4

Max nTPM: 16.1
Min nTPM: 12.4

Sample A		13.4
Sample A		16.1
Sample A		12.6
Sample A		12.4