On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
No data
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.
Scroll down to view mRNA expression data in more detail.
HPA Brain:
0.9
nTPM
HYPOTHALAMUS - SINGLE NUCLEI RNA EXPRESSIONi
RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right).
- UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon
- The BAR CHART shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.
SINGLE NUCLEI BRAIN - HYPOTHALAMUS, NEURONSi
RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right).
- UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon
- The BAR CHART shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.
Cell type color
Cluster color
Colored according to cell type group
Colored according to clusters
Read count filter:0
Cluster
Cell type
Expression (nCPM)
c-1
Unassigned AVP+
c-2
Excitatory (VGLUT2) TAC1+
c-3
Inhibitory (GAD1/2) AVP+
c-4
Unassigned AVP+
c-5
Excitatory (VGLUT2)
c-6
Excitatory (VGLUT2)
c-7
Inhibitory (GAD1/2) DRD2+ L...
c-8
Inhibitory (GAD1/2) ESR1+
c-9
Excitatory (VGLUT2)
c-10
Excitatory (VGLUT2) TAC1+
c-11
Inhibitory (GAD1/2) ESR1+
c-12
Inhibitory (GAD1/2) DRD1+ L...
c-13
Excitatory (VGLUT2)
c-14
Inhibitory (GAD1/2)
c-15
Excitatory (VGLUT2)
c-16
Excitatory (VGLUT2)
c-17
Inhibitory (GAD1/2)
c-18
Inhibitory (GAD1/2) GAL+
c-19
Excitatory (VGLUT1)
c-20
Excitatory (VGLUT2) ESR1+
c-21
Inhibitory (GAD1/2) DRD1+ L...
c-22
Inhibitory (GAD1/2) RORB+ K
c-23
Inhibitory (GAD1/2) SST+ NP
c-24
Inhibitory (GAD1/2) CXCL14+
c-25
Excitatory (VGLUT2)
c-26
Inhibitory (GAD1/2)
c-27
Excitatory (VGLUT2)
c-28
Unassigned
c-29
Inhibitory (GAD1/2) ESR1+
c-30
Excitatory (VGLUT2)
c-31
Excitatory (VGLUT1/2)
c-32
Inhibitory (GAD1/2) GAL+
c-33
Excitatory (VGLUT2)
c-34
Monoaminergic Inhibitory (G...
c-35
Excitatory (VGLUT2) TAC1+
c-36
Inhibitory (GAD1/2) LHX6+ T...
c-37
Excitatory (VGLUT2)
c-38
Inhibitory (GAD1/2) SST+
c-39
Inhibitory (GAD1/2) MEIS2+
c-40
Unassigned
c-41
Inhibitory (GAD1/2) SST+
c-42
Excitatory (VGLUT1)
c-43
Excitatory (VGLUT2) TAC1+
c-44
Unassigned AVP+
c-45
Inhibitory (GAD1/2) LAMP5+ ...
c-46
Excitatory (VGLUT2)
c-47
Inhibitory (GAD1/2) LHX6+ T...
c-48
Parvocellular CRH+ AVP+ OXT
c-49
Magnocellular TH+ AVP+ OXT+
c-50
Excitatory (VGLUT1)
c-51
Parvocellular (VGLUT2) AVP...
c-52
Inhibitory (GAD1/2) NOS1+ M...
c-53
Inhibitory (GAD1/2) TAC1+ D...
c-54
Inhibitory (GAD1/2) SST+
c-55
Excitatory (VGLUT1)
c-56
Excitatory (VGLUT1) ETV1+ Z...
c-57
HCRT+ RXF4+
c-58
Excitatory (VGLUT1/2) TAC1+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview
SINGLE NUCLEI BRAIN - HYPOTHALAMUS, NON-NEURONALi
RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right).
- UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon
- The BAR CHART shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.
Cell type color
Cluster color
Colored according to cell type group
Colored according to clusters
Read count filter:0
Cluster
Cell type
Expression (nCPM)
c-1
Oligodendrocytes
c-2
Oligodendrocytes
c-3
Oligodendrocytes
c-4
Astrocytes (LHX2+)
c-5
Microglia
c-6
Oligodendrocytes
c-7
Astrocytes (CD44+)
c-8
Oligodendrocytes
c-9
Oligodendrocyte progenitor ...
c-10
Microglia
c-11
Oligodendrocytes
c-12
Astrocytes
c-13
Astrocytes (CD44+)
c-14
Oligodendrocyte progenitor ...
c-15
Oligodendrocyte progenitor ...
c-16
Microglia
c-17
Oligodendrocytes
c-18
Oligodendrocyte progenitor ...
c-19
Astrocytes
c-20
Fibroblasts
c-21
Oligodendrocytes
c-22
Oligodendrocytes
c-23
Ependymal cells
c-24
Vascular endothelial cells
c-25
Astrocytes (LHX2+)
c-26
Macrophages
c-27
Astrocytes
c-28
T-cells
c-29
Vascular smooth muscle cell
c-30
Fibroblasts (BNC2+ KCNMA1+ ...
c-31
Pericytes
c-32
Oligodendrocyte progenitor ...
c-33
Immature oligodendrocytes
c-34
Oligodendrocyte progenitor ...
c-35
NK-cells
c-36
Mural cells
c-37
Monocytes
c-38
Fibroblasts (BNC2+ TRPM3+)
c-39
Lymphocytes
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview
HYPOTHALAMUS - Annotated protein expression
Pending normal tissue analysis
HYPOTHALAMUS - HPA Brain RNA-seq
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
0.9
Sample id
Sample description
nTPM
Arcuate nucleus nTPM: 0.9
1961
Female, age 42, unknown
0.9
2226
Male, age 75, left hemisphere
0.8
Dorsomedial nucleus nTPM: 0.8
2017
Female, age 42, unknown
0.8
1989
Male, age 62, unknown
0.7
2041
Female, age 72, unknown
0.7
Lateral hypothalamic area nTPM: 0.8
2271
Male, age 75, both hemispheres
1.0
1791
Male, age 80, right hemisphere
0.8
2412
Male, age 62, unknown
0.8
2228
Male, age 66, unknown
0.7
Mammillary body nTPM: 0.7
1948
Female, age 72, unknown
0.8
1923
Female, age 72, unknown
0.7
1945
Male, age 80, right hemisphere
0.7
1834
Female, age 42, unknown
0.6
2413
Male, age 66, unknown
0.6
Paraventricular nucleus nTPM: 0.9
2700
Male, age 62, unknown
0.9
Preoptic area nTPM: 0.8
1861
Female, age 42, unknown
0.9
2414
Female, age 72, unknown
0.9
1907
Male, age 80, right hemisphere
0.6
Supraoptic nucleus nTPM: 0.9
2835
Female, age 72, unknown
1.1
2043
Male, age 62, unknown
0.9
1894
Female, age 72, unknown
0.8
Ventromedial nucleus nTPM: 0.8
1822
Female, age 42, unknown
0.8
1982
Female, age 72, unknown
0.7
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