On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
No data
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.
Scroll down to view mRNA expression data in more detail.
HPA Brain:
1.1
nTPM
FANTOM5:
0.0
Scaled Tags Per Million
SPINAL CORD - SINGLE NUCLEI RNA EXPRESSIONi
RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right).
- UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon
- The BAR CHART shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.
SINGLE NUCLEI BRAIN - SPINAL CORD, NEURONSi
RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right).
- UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon
- The BAR CHART shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.
Cell type color
Cluster color
Colored according to cell type group
Colored according to clusters
Read count filter:0
Cluster
Cell type
Expression (nCPM)
c-1
Excitatory (VGLUT1) ETV1+ Z...
c-2
Excitatory (VGLUT2) SST+ GR...
c-3
Excitatory (VGLUT2)
c-4
Excitatory (VGLUT2) SST+ CX...
c-5
Excitatory (VGLUT2) SST+ TA...
c-6
Excitatory (VGLUT2) SST+ CA...
c-7
Excitatory (VGLUT2) SST+
c-8
Excitatory (VGLUT2) CXCL14+
c-9
Excitatory (VGLUT2) SST+
c-10
Inhibitory (GAD1/2) SLC6A5+...
c-11
Inhibitory (GAD1/2) PENK+ E...
c-12
Inhibitory (GAD1/2) SLC6A5+...
c-13
Excitatory (VGLUT2)
c-14
Excitatory (VGLUT2) CALB1+
c-15
Inhibitory (GAD1/2) SLC6A5+...
c-16
CALB1+ TRH+
c-17
Inhibitory (GAD1/2) SLC6A5+
c-18
Inhibitory (GAD1/2) SLC6A5+...
c-19
Inhibitory (GAD1/2) SLC6A5+...
c-20
Excitatory (VGLUT2) PENK+ T...
c-21
Inhibitory (GAD2) SLC6A5+ N
c-22
Inhibitory (GAD1/2) TAC1+ K...
c-23
Inhibitory (GAD1/2) SLC6A5+...
c-24
Excitatory (VGLUT2) TAC1+
c-25
Excitatory (VGLUT2)
c-26
Inhibitory (GAD1/2) SLC6A5+
c-27
Excitatory (VGLUT2) SST+ CA...
c-28
Inhibitory (GAD1/2) SLC6A5+...
c-29
Unassigned
c-30
Excitatory (VGLUT2) PENK+
c-31
Inhibitory (GAD1/2) PVALB+ ...
c-32
Excitatory (VGLUT2) PENK+ S...
c-33
Excitatory (VGLUT2)
c-34
Excitatory (VGLUT2) SST+ TA...
c-35
Excitatory (VGLUT2)
Show allShow less
This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview
SINGLE NUCLEI BRAIN - SPINAL CORD, NON-NEURONALi
RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right).
- UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon
- The BAR CHART shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.
Cell type color
Cluster color
Colored according to cell type group
Colored according to clusters
Read count filter:0
Cluster
Cell type
Expression (nCPM)
c-1
Oligodendrocytes
c-2
Oligodendrocytes
c-3
Oligodendrocytes
c-4
Oligodendrocytes
c-5
Oligodendrocyte progenitor ...
c-6
Oligodendrocytes
c-7
Microglia
c-8
Astrocytes (CD44+)
c-9
Astrocytes (CD44+)
c-10
Astrocytes
c-11
Lymphocytes
c-12
Vascular endothelial cells
c-13
Microglia (SPP1+ HIF1A+)
c-14
Ependymal cells
c-15
Oligodendrocyte & OPC doubl
c-16
Pericytes
c-17
Fibroblasts
c-18
Immature oligodendrocytes
c-19
Macrophages
c-20
Myelinating schwann cells
This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview
SPINAL CORD - Annotated protein expression
Pending normal tissue analysis
SPINAL CORD - HPA Brain Stereo-seq
SPINAL CORD - HPA Brain RNA-seq
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
1.1
Sample id
Sample description
nTPM
Anterior funiculus (white matter) nTPM: 1.0
2819
Male, age 47, both hemispheres
1.1
2734
Male, age 80, both hemispheres
1.0
2193
Male, age 75, both hemispheres
0.9
2818
Female, age 79, both hemispheres
0.9
Cervical spinal cord, central gray nTPM: 0.9
1981
Female, age 72, midline
1.0
2194
Female, age 79, both hemispheres
1.0
2816
Male, age 47, midline
1.0
2565
Male, age 75, midline
0.8
2048
Male, age 55, midline
0.7
Cervical spinal cord, dorsal horn nTPM: 0.9
2296
Male, age 66, both hemispheres
1.3
1877
Male, age 55, unknown
0.8
2069
Male, age 47, both hemispheres
0.8
2173
Female, age 72, unknown
0.8
2297
Male, age 75, both hemispheres
0.7
2721
Male, age 90, both hemispheres
0.7
Cervical spinal cord, ventral horn nTPM: 0.8
2098
Female, age 72, unknown
1.0
2480
Male, age 75, both hemispheres
1.0
2820
Female, age 79, both hemispheres
1.0
2068
Male, age 55, unknown
0.9
2295
Male, age 66, both hemispheres
0.7
2809
Male, age 90, both hemispheres
0.4
Dorsal funiculus (white matter) nTPM: 1.1
2810
Male, age 90, both hemispheres
1.7
2064
Female, age 79, both hemispheres
1.1
2128
Male, age 75, both hemispheres
0.9
2812
Male, age 66, both hemispheres
0.9
2817
Male, age 47, both hemispheres
0.9
Lateral funiculus (white matter) nTPM: 1.1
2099
Male, age 90, both hemispheres
1.2
2094
Female, age 79, both hemispheres
1.1
2192
Male, age 75, both hemispheres
1.0
2294
Male, age 66, both hemispheres
0.9
SPINAL CORD - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.
Max subtype Scaled Tags Per Millioni
Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.
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