MSL3

GENERAL INFORMATION

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Gene name

MSL3

Gene description

Male-specific lethal 3 homolog (Drosophila)

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear and sometimes cytoplasmic expression was observed in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA034535 , HPA034536
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MSL3 (HGNC Symbol)

Synonyms

MSL3L1

Description

Male-specific lethal 3 homolog (Drosophila) (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]

Chromosome

X

Cytoband

p22.2

Chromosome location (bp)

11758159 - 11775753

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000005302 (version 78.38)

Entrez gene

10943

UniProt

Q8N5Y2 (UniProt - Evidence at protein level)

neXtProt

NX_Q8N5Y2

Antibodypedia

MSL3 antibodies


PROTEIN BROWSER

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ENST00000312196
 
ENST00000337339
 
ENST00000361672
 
ENST00000380692
 
ENST00000380693
 
ENST00000398527
 
ENST00000421368
 
ENST00000476743
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MSL3-001 ENSP00000338078
ENST00000337339
Q8N5Y2
Show all »
Show » Show » 416 48 No 0
MSL3-003 ENSP00000401809
ENST00000421368
C9JKR8
Show all »
Show » Show » 224 26 No 0
MSL3-004 ENSP00000370068
ENST00000380692
A6NLU8
Show all »
Show » Show » 196 22.6 No 0
MSL3-009 ENSP00000312244
ENST00000312196
Q8N5Y2
Show all »
Show » Show » 521 59.8 No 0
MSL3-010 ENSP00000370069
ENST00000380693
Q8N5Y2
Show all »
Show » Show » 355 40.6 No 0
MSL3-013 ENSP00000419976
ENST00000476743
Show » 19 2.3 No 0
MSL3-201 ENSP00000354562
ENST00000361672
Q8N5Y2
Show all »
Show » Show » 372 42.7 No 0
MSL3-202 ENSP00000381538
ENST00000398527
Q8N5Y2
Show all »
Show » Show » 509 58.2 No 0