ARHGEF1

GENERAL INFORMATION

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Gene name

ARHGEF1

Gene description

Rho guanine nucleotide exchange factor (GEF) 1

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression mainly in lymphoid tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA012924 , CAB009502
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ARHGEF1 (HGNC Symbol)

Synonyms

LBCL2, P115-RHOGEF, SUB1.5

Description

Rho guanine nucleotide exchange factor (GEF) 1 (HGNC Symbol)

Entrez gene summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.2

Chromosome location (bp)

41883161 - 41930150

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000076928 (version 78.38)

Entrez gene

9138

UniProt

Q92888 (UniProt - Evidence at protein level)

neXtProt

NX_Q92888

Antibodypedia

ARHGEF1 antibodies


PROTEIN BROWSER

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ENST00000337665
 
ENST00000347545
 
ENST00000354532
 
ENST00000378152
 
ENST00000594258
 
ENST00000594417
 
ENST00000594521
 
ENST00000595723
 
ENST00000599589
 
ENST00000599846
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARHGEF1-001 ENSP00000344429
ENST00000347545
Q92888
Show all »
Show » Show » 879 98.8 No 0
ARHGEF1-005 ENSP00000346532
ENST00000354532
Q92888
Show all »
Show » Show » 912 102.4 No 0
ARHGEF1-006 ENSP00000337261
ENST00000337665
Q92888
Show all »
Show » Show » 927 104.1 No 0
ARHGEF1-007 ENSP00000367394
ENST00000378152
Q6NX52
Show all »
Show » Show » 948 105.9 No 0
ARHGEF1-009 ENSP00000469735
ENST00000599589
Show » Show » 702 78.5 No 0
ARHGEF1-010 ENSP00000470715
ENST00000599846
M0QZR4
Show all »
Show » Show » 968 108.3 No 0
ARHGEF1-015 ENSP00000470557
ENST00000594521
M0QZH8
Show all »
Show » Show » 275 30 No 0
ARHGEF1-017 ENSP00000470042
ENST00000594258
Show » Show » 307 34.2 No 0
ARHGEF1-022 ENSP00000472466
ENST00000595723
Show » Show » 291 32.8 No 0
ARHGEF1-024 ENSP00000471942
ENST00000594417
Show » 128 13.9 No 0