DYRK4

GENERAL INFORMATION

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Gene name

DYRK4

Gene description

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in testis RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 2 antibodies.
HPA028065 , HPA056073
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

DYRK4

Synonyms

Description

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

Chromosome

12

Cytoband

p13.32

Chromosome location (bp)

4562204 - 4615302

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000010219 (version 78.38)

Entrez gene

8798

UniProt

Q9NR20 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NR20

Antibodypedia

DYRK4 antibodies


PROTEIN BROWSER

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ENST00000010132
 
ENST00000540757
 
ENST00000543431
 
ENST00000544671
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DYRK4-001 ENSP00000441755
ENST00000540757
Q9NR20
Show all »
Show » Show » 520 59.6 No 0
DYRK4-003 ENSP00000439697
ENST00000543431
B4E1A4
Show all »
Show » Show » 634 72.5 No 0
DYRK4-014 ENSP00000438769
ENST00000544671
Show » Show » 120 13.8 No 0
DYRK4-201 ENSP00000010132
ENST00000010132
Q9NR20
Show all »
Show » Show » 520 59.6 No 0