MAP4K5

GENERAL INFORMATION

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Gene name

MAP4K5

Gene description

Mitogen-activated protein kinase kinase kinase kinase 5

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in a subset of tissues, mainly smooth muscle.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA036696
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MAP4K5 (HGNC Symbol)

Synonyms

GCKR, KHS, KHS1

Description

Mitogen-activated protein kinase kinase kinase kinase 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q22.1

Chromosome location (bp)

50418501 - 50561126

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000012983 (version 78.38)

Entrez gene

11183

UniProt

neXtProt

Antibodypedia

MAP4K5 antibodies


PROTEIN BROWSER

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ENST00000013125
 
ENST00000554273
 
ENST00000555216
 
ENST00000557390
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP4K5-001 ENSP00000013125
ENST00000013125
G3V4T8
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Show » Show » 846 95 No 0
MAP4K5-004 ENSP00000451452
ENST00000554273
G3V3V7
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Show » Show » 56 6.2 No 0
MAP4K5-006 ENSP00000451980
ENST00000557390
G3V4T8
Show all »
Show » Show » 137 15.5 No 0
MAP4K5-008 ENSP00000452289
ENST00000555216
G3V5C6
Show all »
Show » Show » 108 12.1 No 0