KIT

GENERAL INFORMATION

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Gene name

KIT

Gene description

V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Protein class

Cancer-related genes
CD markers
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
RAS pathway related proteins

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic and membranous expression in a few cell types including subset of cells in breast, melanocytes in skin, basket cells in cerebellum and subsets of peripheral immune cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 4 antibodies.
HPA004471 , CAB003288 , CAB068253 , CAB072867
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

KIT (HGNC Symbol)

Synonyms

C-Kit, CD117, PBT, SCFR

Description

V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (HGNC Symbol)

Entrez gene summary

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q12

Chromosome location (bp)

54657918 - 54740715

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157404 (version 78.38)

Entrez gene

3815

UniProt

P10721 (UniProt - Evidence at protein level)

neXtProt

NX_P10721

Antibodypedia

KIT antibodies


PROTEIN BROWSER

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ENST00000288135
 
ENST00000412167
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KIT-001 ENSP00000288135
ENST00000288135
P10721
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Show » Show » 976 109.9 Yes 1
KIT-002 ENSP00000390987
ENST00000412167
P10721
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Show » Show » 972 109.5 Yes 1