TNFRSF1B

GENERAL INFORMATION

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Gene name

TNFRSF1B

Gene description

Tumor necrosis factor receptor superfamily, member 1B

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
CD markers
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Positivity in extracellular deposits. Cytoplasmic and membranous expression in several different cell types.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA004796 , CAB013045
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

TNFRSF1B (HGNC Symbol)

Synonyms

CD120b, p75, TNF-R-II, TNF-R75, TNFBR, TNFR2, TNFR80

Description

Tumor necrosis factor receptor superfamily, member 1B (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.22

Chromosome location (bp)

12167003 - 12209228

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000028137 (version 78.38)

Entrez gene

7133

UniProt

P20333 (UniProt - Evidence at protein level)

neXtProt

NX_P20333

Antibodypedia

TNFRSF1B antibodies


PROTEIN BROWSER

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ENST00000376259
 
ENST00000536782
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFRSF1B-001 ENSP00000365435
ENST00000376259
P20333
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Show » Show » 461 48.3 Yes 1
TNFRSF1B-201 ENSP00000440425
ENST00000536782
B5A977
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Show » Show » 155 17 Yes 0