CDH1

GENERAL INFORMATION

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Gene name

CDH1

Gene description

Cadherin 1, type 1, E-cadherin (epithelial)

Protein class

Cancer-related genes
CD markers
Disease related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and membranous expression in epithelial cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 6 antibodies.
HPA004812 , CAB000087 , CAB028364 , CAB072855 , CAB072856 , CAB072857
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

CDH1 (HGNC Symbol)

Synonyms

CD324, UVO, uvomorulin

Description

Cadherin 1, type 1, E-cadherin (epithelial) (HGNC Symbol)

Entrez gene summary

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q22.1

Chromosome location (bp)

68737225 - 68835548

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000039068 (version 78.38)

Entrez gene

999

UniProt

P12830 (UniProt - Evidence at protein level)

neXtProt

NX_P12830

Antibodypedia

CDH1 antibodies


PROTEIN BROWSER

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ENST00000261769
 
ENST00000422392
 
ENST00000611625
 
ENST00000612417
 
ENST00000621016
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDH1-001 ENSP00000261769
ENST00000261769
P12830
Show all »
Show » Show » 882 97.5 Yes 1
CDH1-004 ENSP00000414946
ENST00000422392
P12830
Show all »
Show » Show » 821 90.9 Yes 1
CDH1-201 ENSP00000481063
ENST00000611625
Show » Show » 903 100 Yes 1
CDH1-202 ENSP00000478360
ENST00000612417
Show » Show » 647 71.3 Yes 0
CDH1-203 ENSP00000480664
ENST00000621016
Show » Show » 647 71.4 Yes 0