BEST2

GENERAL INFORMATION

? »

Gene name

BEST2

Gene description

Bestrophin 2

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Group enriched (colon, rectum, tonsil)
GTEx:Group enriched (colon, skin, small intestine)

Protein evidence

Evidence at transcript level

Protein localization

Cytoplasmic expression in goblet cells is colon and rectum

ANTIBODY RELIABILITY

? »

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA046229
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Group enriched (colon, rectum, tonsil)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (colon, skin, small intestine)

Organ

Expression



GENE INFORMATION

? »

Gene name

BEST2 (HGNC Symbol)

Synonyms

FLJ20132, VMD2L1

Description

Bestrophin 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the retinal pigment epithelium and colon. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.13

Chromosome location (bp)

12751702 - 12758458

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000039987 (version 78.38)

Entrez gene

54831

UniProt

Q8NFU1 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8NFU1

Antibodypedia

BEST2 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000042931
 
ENST00000549706
 
ENST00000552539
 
ENST00000553030
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BEST2-001 ENSP00000447203
ENST00000553030
Q8NFU1
Show all »
Show » Show » 509 57.1 No 4
BEST2-002 ENSP00000448310
ENST00000549706
Q8NFU1
Show all »
Show » Show » 509 57.1 No 4
BEST2-003 ENSP00000449403
ENST00000552539
Show » 78 8.9 No 0
BEST2-201 ENSP00000042931
ENST00000042931
Q8NFU1
Show all »
Show » Show » 509 57.1 No 4