USP28

GENERAL INFORMATION

? »

Gene name

USP28

Gene description

Ubiquitin specific peptidase 28

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

? »

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA006778 , HPA006779
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

USP28 (HGNC Symbol)

Synonyms

KIAA1515

Description

Ubiquitin specific peptidase 28 (HGNC Symbol)

Entrez gene summary

The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).[supplied by OMIM, Mar 2008]

Chromosome

11

Cytoband

q23.2

Chromosome location (bp)

113797874 - 113875570

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000048028 (version 78.38)

Entrez gene

57646

UniProt

Q96RU2 (UniProt - Evidence at protein level)

neXtProt

NX_Q96RU2

Antibodypedia

USP28 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000003302
 
ENST00000537642
 
ENST00000537706
 
ENST00000538224
 
ENST00000538475
 
ENST00000540925
 
ENST00000544750
 
ENST00000544967
 
ENST00000545540
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

USP28-001 ENSP00000003302
ENST00000003302
Q96RU2
Show all »
Show » Show » 1077 122.5 No 0
USP28-002 ENSP00000445743
ENST00000537706
Q6NZX9
Show all »
Show » Show » 583 66.2 No 0
USP28-004 ENSP00000444991
ENST00000545540
B4E3L3
Show all »
Show » Show » 920 105.8 No 0
USP28-006 ENSP00000442431
ENST00000544967
G3V1N5
Show all »
Show » Show » 753 86.3 No 0
USP28-007 ENSP00000446284
ENST00000540925
F5H2G4
Show all »
Show » Show » 77 8.7 No 0
USP28-008 ENSP00000437450
ENST00000544750
F5H6Q3
Show all »
Show » Show » 46 5.3 No 0
USP28-009 ENSP00000440799
ENST00000537642
H0YFX3
Show all »
Show » Show » 244 27.8 No 0
USP28-012 ENSP00000442257
ENST00000538475
H0YG96
Show all »
Show » Show » 360 41.9 No 0
USP28-014 ENSP00000440260
ENST00000538224
Show » 194 21.5 No 0