IDH3B

GENERAL INFORMATION

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Gene name

IDH3B

Gene description

Isocitrate dehydrogenase 3 (NAD+) beta

Protein class

Citric acid cycle related proteins
Disease related genes
Enzymes
Mitochondrial proteins
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression in a granular pattern.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA049387
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

IDH3B (HGNC Symbol)

Synonyms

RP46

Description

Isocitrate dehydrogenase 3 (NAD+) beta (HGNC Symbol)

Entrez gene summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

p13

Chromosome location (bp)

2658395 - 2664219

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101365 (version 78.38)

Entrez gene

3420

UniProt

O43837 (UniProt - Evidence at protein level)

neXtProt

NX_O43837

Antibodypedia

IDH3B antibodies


PROTEIN BROWSER

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ENST00000380843
 
ENST00000380851
 
ENST00000474315
 
ENST00000613370
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IDH3B-001 ENSP00000482773
ENST00000474315
Q9UIC5
Show all »
Show » Show » 387 42.4 No 0
IDH3B-010 ENSP00000370232
ENST00000380851
O43837
Show all »
Show » Show » 383 41.9 No 0
IDH3B-011 ENSP00000370223
ENST00000380843
O43837
Show all »
Show » Show » 385 42.2 No 0
IDH3B-201 ENSP00000484922
ENST00000613370
B4DU38
Show all »
Show » Show » 376 41.2 No 0