ADAMTS6

GENERAL INFORMATION

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Gene name

ADAMTS6

Gene description

ADAM metallopeptidase with thrombospondin type 1 motif, 6

Protein class

Cancer-related genes
Enzymes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Granular cytoplasmic expression in placental trophoblasts and ovarian follicle cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding in intestine observed and disregarded.

Data reliability

Supportive based on 1 antibody.
HPA043441
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

ADAMTS6 (HGNC Symbol)

Synonyms

ADAM-TS6

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q12.3

Chromosome location (bp)

65148736 - 65481920

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000049192 (version 78.38)

Entrez gene

11174

UniProt

Q9UKP5 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9UKP5

Antibodypedia

ADAMTS6 antibodies


PROTEIN BROWSER

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ENST00000381055
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS6-007 ENSP00000370443
ENST00000381055
Q9UKP5
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