ATP2B3

GENERAL INFORMATION

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Gene name

ATP2B3

Gene description

ATPase, Ca++ transporting, plasma membrane 3

Protein class

Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (adrenal gland, cerebral cortex)
GTEx:Group enriched (adrenal gland, cerebellum, cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in CNS, including granular layer and Purkinje cells in cerebellum.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. External characterization data supports antibody staining.

Data reliability

Supportive based on 1 antibody.
HPA001583
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (adrenal gland, cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (adrenal gland, cerebellum, cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

ATP2B3 (HGNC Symbol)

Synonyms

CFAP39, CLA2, PMCA3, SCAX1

Description

ATPase, Ca++ transporting, plasma membrane 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q28

Chromosome location (bp)

153517676 - 153582939

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000067842 (version 78.38)

Entrez gene

492

UniProt

Q16720 (UniProt - Evidence at protein level)

neXtProt

NX_Q16720

Antibodypedia

ATP2B3 antibodies


PROTEIN BROWSER

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ENST00000263519
 
ENST00000349466
 
ENST00000359149
 
ENST00000370186
 
ENST00000393842
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP2B3-001 ENSP00000359205
ENST00000370186
Q16720
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Show » Show » 1159 127.1 No >9
ATP2B3-002 ENSP00000343886
ENST00000349466
Q16720
Show all »
Show » Show » 1220 134.2 No >9
ATP2B3-004 ENSP00000377425
ENST00000393842
Q16720
Show all »
Show » Show » 1154 126.6 No >9
ATP2B3-006 ENSP00000352062
ENST00000359149
Q16720
Show all »
Show » Show » 1173 128.5 No >9
ATP2B3-201 ENSP00000263519
ENST00000263519
Q16720
Show all »
Show » Show » 1220 134.2 No >9