CRHR2

GENERAL INFORMATION

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Gene name

CRHR2

Gene description

Corticotropin releasing hormone receptor 2

Protein class

G-protein coupled receptors
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

RNA-based expert annotation could not be performed.

ANTIBODY RELIABILITY

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Data reliability
description

Presumed off target binding observed and disregarded. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA046683
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

CRHR2 (HGNC Symbol)

Synonyms

CRF-RB, CRF2, HM-CRF

Description

Corticotropin releasing hormone receptor 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

Chromosome

7

Cytoband

p14.3

Chromosome location (bp)

30651943 - 30700129

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106113 (version 78.38)

Entrez gene

1395

UniProt

Q13324 (UniProt - Evidence at protein level)

neXtProt

NX_Q13324

Antibodypedia

CRHR2 antibodies


PROTEIN BROWSER

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ENST00000341843
 
ENST00000348438
 
ENST00000445981
 
ENST00000471646
 
ENST00000506074
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRHR2-001 ENSP00000340943
ENST00000348438
Q13324
Show all »
Show » Show » 438 50.8 Yes 7
CRHR2-002 ENSP00000418722
ENST00000471646
Q13324
Show all »
Show » Show » 411 47.7 No 7
CRHR2-006 ENSP00000401241
ENST00000445981
C9JZM9
Show all »
Show » 99 11 Yes 0
CRHR2-201 ENSP00000344304
ENST00000341843
Q13324
Show all »
Show » Show » 397 46.5 No 7
CRHR2-202 ENSP00000426498
ENST00000506074
Q13324
Show all »
Show » Show » 387 44.8 Yes 7