ASIC4

GENERAL INFORMATION

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Gene name

ASIC4

Gene description

Acid-sensing (proton-gated) ion channel family member 4

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebellum, cerebral cortex, hippocampus, testis)

Protein evidence

Evidence at protein level

Protein localization

External data suggests expression in pituitary gland. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification. Presumed off target binding observed and disregarded. Pending additional tissues.

Data reliability

Uncertain based on 2 antibodies.
HPA036042 , CAB032529
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum, cerebral cortex, hippocampus, testis)

Organ

Expression



GENE INFORMATION

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Gene name

ASIC4 (HGNC Symbol)

Synonyms

ACCN4, BNAC4

Description

Acid-sensing (proton-gated) ion channel family member 4 (HGNC Symbol)

Entrez gene summary

This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]

Chromosome

2

Cytoband

q35

Chromosome location (bp)

219514170 - 219538772

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000072182 (version 78.38)

Entrez gene

55515

UniProt

Q96FT7 (UniProt - Evidence at protein level)

neXtProt

NX_Q96FT7

Antibodypedia

ASIC4 antibodies


PROTEIN BROWSER

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ENST00000347842
 
ENST00000358078
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ASIC4-001 ENSP00000326627
ENST00000347842
Q96FT7
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Show » Show » 647 70.1 No 2
ASIC4-002 ENSP00000350786
ENST00000358078
Q96FT7
Show all »
Show » Show » 666 72.2 No 2