KCNK2

GENERAL INFORMATION

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Gene name

KCNK2

Gene description

Potassium channel, subfamily K, member 2

Protein class

FDA approved drug targets
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (adrenal gland)
GTEx:Tissue enriched (adrenal gland)

Protein evidence

Evidence at protein level

Protein localization

RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA056054
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (adrenal gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (adrenal gland)

Organ

Expression



GENE INFORMATION

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Gene name

KCNK2 (HGNC Symbol)

Synonyms

K2p2.1, TREK-1

Description

Potassium channel, subfamily K, member 2 (HGNC Symbol)

Entrez gene summary

This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q41

Chromosome location (bp)

215005775 - 215237093

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000082482 (version 78.38)

Entrez gene

3776

UniProt

O95069 (UniProt - Evidence at protein level)

neXtProt

NX_O95069

Antibodypedia

KCNK2 antibodies


PROTEIN BROWSER

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ENST00000391894
 
ENST00000391895
 
ENST00000444842
 
ENST00000457122
 
ENST00000478774
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNK2-001 ENSP00000394033
ENST00000444842
O95069
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Show » Show » 426 47.1 No 6
KCNK2-002 ENSP00000375764
ENST00000391894
O95069
Show all »
Show » Show » 411 45.5 No 6
KCNK2-003 ENSP00000413460
ENST00000457122
C9JXY2
Show all »
Show » Show » 125 13.7 No 2
KCNK2-008 ENSP00000375765
ENST00000391895
O95069
Show all »
Show » Show » 422 46.9 No 6
KCNK2-011 ENSP00000420569
ENST00000478774
C9JDK1
Show all »
Show » Show » 118 12.9 No 2