The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Moderate cytoplasmic positivity with additional membranous positivity were displayed in breast, urothelial, pancreatic, skin, lung, endometrial cancers, melanomas and carcinoids. Lymphomas and seminomas were negative.
Weak to moderate membranous and/or cytoplasmic staining was observed in several cases of most cancers. Several cases of malignant melanoma and a few of urothelial cancers displayed strong immunoreactivity. Prostate cancer, malignant carcinoid, malignant glioma, malignant lymphoma and testis cancer were in general negative.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
