CD59

GENERAL INFORMATION

? »

Gene name

CD59

Gene description

CD59 molecule, complement regulatory protein

Protein class

Cancer-related genes
CD markers
Disease related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Membranous and cytoplasmic expression in selected tissues.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA026494 , CAB001448
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

CD59 (HGNC Symbol)

Synonyms

16.3A5, EJ16, EJ30, EL32, G344, MIC11, MIN1, MIN2, MIN3, MSK21, p18-20

Description

CD59 molecule, complement regulatory protein (HGNC Symbol)

Entrez gene summary

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p13

Chromosome location (bp)

33698261 - 33736445

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000085063 (version 78.38)

Entrez gene

966

UniProt

P13987 (UniProt - Evidence at protein level)

neXtProt

NX_P13987

Antibodypedia

CD59 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000351554
 
ENST00000395850
 
ENST00000415002
 
ENST00000426650
 
ENST00000437761
 
ENST00000445143
 
ENST00000527577
 
ENST00000528700
 
ENST00000533403
 
ENST00000534312
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD59-001 ENSP00000340210
ENST00000351554
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-002 ENSP00000379191
ENST00000395850
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-003 ENSP00000404822
ENST00000415002
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-005 ENSP00000432942
ENST00000527577
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-006 ENSP00000434617
ENST00000528700
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-007 ENSP00000402425
ENST00000426650
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-008 ENSP00000403511
ENST00000445143
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-009 ENSP00000410182
ENST00000437761
P13987
Show all »
Show » Show » 128 14.2 Yes 1
CD59-010 ENSP00000436737
ENST00000533403
E9PI80
Show all »
Show » Show » 119 13 Yes 0
CD59-012 ENSP00000432362
ENST00000534312
E9PR17
Show all »
Show » Show » 130 14.5 Yes 0