ADD1

GENERAL INFORMATION

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Gene name

ADD1

Gene description

Adducin 1 (alpha)

Protein class

Cytoskeleton related proteins
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

13
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cellmembranous expression in many tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA035873 , HPA035874 , CAB009794
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ADD1

Synonyms

Description

Adducin 1 (alpha) (HGNC Symbol)

Entrez gene summary

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

p16.3

Chromosome location (bp)

2843857 - 2930076

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000087274 (version 78.38)

Entrez gene

118

UniProt

P35611 (UniProt - Evidence at protein level)

neXtProt

NX_P35611

Antibodypedia

ADD1 antibodies


PROTEIN BROWSER

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 « 
 
ENST00000264758
 
ENST00000355842
 
ENST00000398123
 
ENST00000398125
 
ENST00000398129
 
ENST00000446856
 
ENST00000503455
 
ENST00000508277
 
ENST00000511797
 
ENST00000513328
 
ENST00000514940
 
ENST00000536424
 
ENST00000541843
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADD1-001 ENSP00000381197
ENST00000398129
P35611
Show all »
Show » Show » 737 81 No 0
ADD1-002 ENSP00000348100
ENST00000355842
P35611
Show all »
Show » Show » 662 73.4 No 0
ADD1-003 ENSP00000381191
ENST00000398123
P35611
Show all »
Show » Show » 662 73.3 No 0
ADD1-009 ENSP00000426700
ENST00000508277
D6RF25
Show all »
Show » Show » 143 15.9 No 0
ADD1-011 ENSP00000421918
ENST00000511797
D6RAH3
Show all »
Show » 137 15.3 No 0
ADD1-013 ENSP00000423024
ENST00000503455
E7ENY0
Show all »
Show » Show » 663 73.4 No 0
ADD1-014 ENSP00000421907
ENST00000513328
E7EV99
Show all »
Show » Show » 632 70.1 No 0
ADD1-015 ENSP00000424143
ENST00000514940
Show » 444 48.4 No 0
ADD1-022 ENSP00000438069
ENST00000536424
H0YFD8
Show all »
Show » Show » 105 12.1 No 0
ADD1-023 ENSP00000441388
ENST00000541843
Show » 114 12.8 No 0
ADD1-201 ENSP00000264758
ENST00000264758
P35611
Show all »
Show » Show » 768 84.3 No 0
ADD1-202 ENSP00000381193
ENST00000398125
P35611
Show all »
Show » Show » 662 73.3 No 0
ADD1-203 ENSP00000399828
ENST00000446856
D6RAH3
Show all »
Show » 400 44 No 0