BIRC5

GENERAL INFORMATION

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Gene name

BIRC5

Gene description

Baculoviral IAP repeat containing 5

Protein class

Cancer-related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

Distinct nuclear expression in a fraction of cells in squamous epithelia, lymphoid tissues, gastrointestinal tract, testis and glandular cells of female genitalia.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA002830 , CAB004270
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

BIRC5 (HGNC Symbol)

Synonyms

API4, EPR-1, survivin

Description

Baculoviral IAP repeat containing 5 (HGNC Symbol)

Entrez gene summary

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Chromosome

17

Cytoband

q25.3

Chromosome location (bp)

78214186 - 78225636

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000089685 (version 78.38)

Entrez gene

332

UniProt

O15392 (UniProt - Evidence at protein level)

neXtProt

NX_O15392

Antibodypedia

BIRC5 antibodies


PROTEIN BROWSER

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ENST00000301633
 
ENST00000350051
 
ENST00000374948
 
ENST00000587746
 
ENST00000590449
 
ENST00000592734
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BIRC5-001 ENSP00000324180
ENST00000350051
Show » 142 16.4 No 0
BIRC5-002 ENSP00000364086
ENST00000374948
O15392
Show all »
Show » Show » 137 15.6 No 0
BIRC5-003 ENSP00000465868
ENST00000590449
O15392
Show all »
Show » Show » 74 8.5 No 0
BIRC5-004 ENSP00000301633
ENST00000301633
H3BLT4
Show all »
Show » Show » 165 18.6 No 0
BIRC5-005 ENSP00000466617
ENST00000592734
O15392
Show all »
Show » Show » 78 9 No 0
BIRC5-010 ENSP00000466675
ENST00000587746
A3E0Z5
Show all »
Show » 121 13.4 No 0