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MAPK1
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  • MAPK1
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

MAPK1
Synonyms ERK, ERK2, MAPK2, p41mapk, PRKM1, PRKM2
Gene descriptioni

Full gene name according to HGNC.

Mitogen-activated protein kinase 1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Enzymes
FDA approved drug targets
Human disease related genes
Plasma proteins
RAS pathway related proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 22
Cytoband q11.22
Chromosome location (bp) 21759657 - 21867680
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

3
Ensembl ENSG00000100030 (version 103.38)
Entrez gene 5594
HGNC HGNC:6871
UniProt P28482 (UniProt - Evidence at protein level)
neXtProt NX_P28482
Antibodypedia MAPK1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 1      # Population variants: 50

Experimental

Description: Complex of ERK2 with norathyriol (X-ray)

# Chains: 1      # Clinical variants: 1      # Population variants: 50

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
MAPK1-201
MAPK1-202
MAPK1-204


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
MAPK1-201
ENSP00000215832
ENST00000215832
P28482 [Direct mapping]
Mitogen-activated protein kinase 1
Q1HBJ4 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0001784 [phosphotyrosine residue binding]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006935 [chemotaxis]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007268 [chemical synaptic transmission]
GO:0007411 [axon guidance]
GO:0007507 [heart development]
GO:0007568 [aging]
GO:0007611 [learning or memory]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008353 [RNA polymerase II CTD heptapeptide repeat kinase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009636 [response to toxic substance]
GO:0009887 [animal organ morphogenesis]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0014032 [neural crest cell development]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0014069 [postsynaptic density]
GO:0015966 [diadenosine tetraphosphate biosynthetic process]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019233 [sensory perception of pain]
GO:0019858 [cytosine metabolic process]
GO:0019901 [protein kinase binding]
GO:0019902 [phosphatase binding]
GO:0030168 [platelet activation]
GO:0030278 [regulation of ossification]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030641 [regulation of cellular pH]
GO:0030878 [thyroid gland development]
GO:0031143 [pseudopodium]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0031647 [regulation of protein stability]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032496 [response to lipopolysaccharide]
GO:0032839 [dendrite cytoplasm]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0032991 [protein-containing complex]
GO:0033598 [mammary gland epithelial cell proliferation]
GO:0034198 [cellular response to amino acid starvation]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035094 [response to nicotine]
GO:0035556 [intracellular signal transduction]
GO:0035578 [azurophil granule lumen]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038127 [ERBB signaling pathway]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042473 [outer ear morphogenesis]
GO:0042802 [identical protein binding]
GO:0043204 [perikaryon]
GO:0043312 [neutrophil degranulation]
GO:0043330 [response to exogenous dsRNA]
GO:0043627 [response to estrogen]
GO:0045596 [negative regulation of cell differentiation]
GO:0045727 [positive regulation of translation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046697 [decidualization]
GO:0048538 [thymus development]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051973 [positive regulation of telomerase activity]
GO:0060020 [Bergmann glial cell differentiation]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060291 [long-term synaptic potentiation]
GO:0060324 [face development]
GO:0060425 [lung morphogenesis]
GO:0060440 [trachea formation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061308 [cardiac neural crest cell development involved in heart development]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070849 [response to epidermal growth factor]
GO:0071276 [cellular response to cadmium ion]
GO:0071310 [cellular response to organic substance]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0072584 [caveolin-mediated endocytosis]
GO:0072686 [mitotic spindle]
GO:0090170 [regulation of Golgi inheritance]
GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus]
GO:0120041 [positive regulation of macrophage proliferation]
GO:1900034 [regulation of cellular response to heat]
GO:1903351 [cellular response to dopamine]
GO:1904355 [positive regulation of telomere capping]
GO:1904813 [ficolin-1-rich granule lumen]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
360 aa
41.4 kDa
No 0
MAPK1-202
ENSP00000381803
ENST00000398822
P28482 [Direct mapping]
Mitogen-activated protein kinase 1
Q1HBJ4 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0003677 [DNA binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006935 [chemotaxis]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007268 [chemical synaptic transmission]
GO:0007411 [axon guidance]
GO:0007611 [learning or memory]
GO:0008353 [RNA polymerase II CTD heptapeptide repeat kinase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019902 [phosphatase binding]
GO:0030168 [platelet activation]
GO:0031647 [regulation of protein stability]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0034198 [cellular response to amino acid starvation]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035094 [response to nicotine]
GO:0035556 [intracellular signal transduction]
GO:0035578 [azurophil granule lumen]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038127 [ERBB signaling pathway]
GO:0042802 [identical protein binding]
GO:0043312 [neutrophil degranulation]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051973 [positive regulation of telomerase activity]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070849 [response to epidermal growth factor]
GO:0071276 [cellular response to cadmium ion]
GO:0072584 [caveolin-mediated endocytosis]
GO:0072686 [mitotic spindle]
GO:0090170 [regulation of Golgi inheritance]
GO:0120041 [positive regulation of macrophage proliferation]
GO:1900034 [regulation of cellular response to heat]
GO:1903351 [cellular response to dopamine]
GO:1904355 [positive regulation of telomere capping]
GO:1904813 [ficolin-1-rich granule lumen]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
360 aa
41.4 kDa
No 0
MAPK1-204
ENSP00000440842
ENST00000544786
P28482 [Direct mapping]
Mitogen-activated protein kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0003677 [DNA binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006935 [chemotaxis]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007268 [chemical synaptic transmission]
GO:0007411 [axon guidance]
GO:0007611 [learning or memory]
GO:0008353 [RNA polymerase II CTD heptapeptide repeat kinase activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019902 [phosphatase binding]
GO:0030168 [platelet activation]
GO:0031647 [regulation of protein stability]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0034198 [cellular response to amino acid starvation]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035094 [response to nicotine]
GO:0035556 [intracellular signal transduction]
GO:0035578 [azurophil granule lumen]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038127 [ERBB signaling pathway]
GO:0042802 [identical protein binding]
GO:0043312 [neutrophil degranulation]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051973 [positive regulation of telomerase activity]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070849 [response to epidermal growth factor]
GO:0071276 [cellular response to cadmium ion]
GO:0072584 [caveolin-mediated endocytosis]
GO:0072686 [mitotic spindle]
GO:0090170 [regulation of Golgi inheritance]
GO:0120041 [positive regulation of macrophage proliferation]
GO:1900034 [regulation of cellular response to heat]
GO:1903351 [cellular response to dopamine]
GO:1904355 [positive regulation of telomere capping]
GO:1904813 [ficolin-1-rich granule lumen]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
316 aa
36.4 kDa
No 0

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