SLC25A1

GENERAL INFORMATION

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Gene name

SLC25A1

Gene description

Solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1

Protein class

Disease related genes
Mitochondrial proteins
Potential drug targets
Predicted intracellular proteins
Transporters

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed weak to moderate cytoplasmic positivity. Strong granular cytoplasmic staining was seen in neuronal cells and cardiac myocytes. Exocrine pancreas, glial cells and cells in spleen were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA030183
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SLC25A1 (HGNC Symbol)

Synonyms

CTP, SLC20A3

Description

Solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. Members of this family include nuclear-encoded transporters that translocate small metabolites across the mitochondrial membrane. This protein regulates the movement of citrate across the inner membranes of the mitochondria. Mutations in this gene have been associated with combined D-2- and L-2-hydroxyglutaric aciduria. Pseudogenes of this gene have been identified on chromosomes 7, 11, 16, and 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

19175575 - 19178830

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100075 (version 78.38)

Entrez gene

6576

UniProt

P53007 (UniProt - Evidence at protein level)

neXtProt

NX_P53007

Antibodypedia

SLC25A1 antibodies


PROTEIN BROWSER

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ENST00000215882
 
ENST00000451283
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC25A1-001 ENSP00000215882
ENST00000215882
P53007
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Show » Show » 311 34 No 0
SLC25A1-003 ENSP00000401480
ENST00000451283
B4DP62
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Show » Show » 208 23.2 No 0