PORCN

GENERAL INFORMATION

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Gene name

PORCN

Gene description

Porcupine homolog (Drosophila)

Protein class

Disease related genes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (adrenal gland)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

A few cells in stomach, gall bladder and urinary bladder showed strong staining. Respiratory epithelia, rectum, breast, Leydig cells, prostate and hematopoietic cells showed moderate cytoplasmic staining. Most remaining normal tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA049215
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (adrenal gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PORCN (HGNC Symbol)

Synonyms

DHOF, MG61, por, PORC, PPN

Description

Porcupine homolog (Drosophila) (HGNC Symbol)

Entrez gene summary

This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2013]

Chromosome

X

Cytoband

p11.23

Chromosome location (bp)

48508962 - 48520814

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102312 (version 78.38)

Entrez gene

64840

UniProt

Q9H237 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H237

Antibodypedia

PORCN antibodies


PROTEIN BROWSER

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ENST00000326194
 
ENST00000355092
 
ENST00000355961
 
ENST00000359882
 
ENST00000361988
 
ENST00000367574
 
ENST00000489940
 
ENST00000537758
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PORCN-001 ENSP00000352946
ENST00000359882
Q9H237
Show all »
Show » Show » 455 51.6 No 8
PORCN-002 ENSP00000348233
ENST00000355961
Q9H237
Show all »
Show » Show » 456 51.8 No 8
PORCN-008 ENSP00000419212
ENST00000489940
C9JWI5
Show all »
Show » 97 11.2 No 2
PORCN-010 ENSP00000354978
ENST00000361988
Q9H237
Show all »
Show » Show » 450 51 No 8
PORCN-011 ENSP00000322304
ENST00000326194
Q9H237
Show all »
Show » Show » 461 52.3 No 8
PORCN-201 ENSP00000347207
ENST00000355092
Show » 405 45.8 No 8
PORCN-202 ENSP00000356546
ENST00000367574
Q9H237
Show all »
Show » Show » 455 51.6 No 9
PORCN-203 ENSP00000446401
ENST00000537758
Q9H237
Show all »
Show » Show » 456 51.8 No 9