MAPK11

GENERAL INFORMATION

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Gene name

MAPK11

Gene description

Mitogen-activated protein kinase 11

Protein class

Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression often in a granular pattern.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 2 antibodies.
HPA045069 , CAB012961
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MAPK11 (HGNC Symbol)

Synonyms

p38-2, p38Beta, PRKM11, SAPK2

Description

Mitogen-activated protein kinase 11 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Chromosome

22

Cytoband

q13.33

Chromosome location (bp)

50263713 - 50270767

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185386 (version 78.38)

Entrez gene

5600

UniProt

Q15759 (UniProt - Evidence at protein level)

neXtProt

NX_Q15759

Antibodypedia

MAPK11 antibodies


PROTEIN BROWSER

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ENST00000330651
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAPK11-001 ENSP00000333685
ENST00000330651
Q15759
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