KCNT1

GENERAL INFORMATION

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Gene name

KCNT1

Gene description

Potassium channel, subfamily T, member 1

Protein class

Disease related genes
Potential drug targets
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (cerebral cortex, ovary, skeletal muscle, spleen)
GTEx:Group enriched (cerebellum, cerebral cortex, spleen)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in CNS and spleen. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA059880
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (cerebral cortex, ovary, skeletal muscle, spleen)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum, cerebral cortex, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

KCNT1 (HGNC Symbol)

Synonyms

KCa4.1, KIAA1422

Description

Potassium channel, subfamily T, member 1 (HGNC Symbol)

Entrez gene summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Chromosome

9

Cytoband

q34.3

Chromosome location (bp)

135702185 - 135793150

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107147 (version 78.38)

Entrez gene

57582

UniProt

Q5JUK3 (UniProt - Evidence at protein level)

neXtProt

NX_Q5JUK3

Antibodypedia

KCNT1 antibodies


PROTEIN BROWSER

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ENST00000263604
 
ENST00000371757
 
ENST00000473941
 
ENST00000486577
 
ENST00000487664
 
ENST00000488444
 
ENST00000490355
 
ENST00000491806
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNT1-001 ENSP00000417851
ENST00000487664
Q5JUK3
Show all »
Show » Show » 1211 137 No 7
KCNT1-002 ENSP00000360822
ENST00000371757
Q5JUK3
Show all »
Show » Show » 1235 139.7 No 8
KCNT1-004 ENSP00000419086
ENST00000491806
C9JYL2
Show all »
Show » Show » 1221 137.4 No 8
KCNT1-005 ENSP00000419007
ENST00000488444
C9JZ51
Show all »
Show » Show » 1235 138.9 No 8
KCNT1-006 ENSP00000418003
ENST00000490355
C9JAX7
Show all »
Show » Show » 1234 138.9 No 8
KCNT1-007 ENSP00000417578
ENST00000486577
C9J9Y7
Show all »
Show » Show » 1213 137.6 No 8
KCNT1-010 ENSP00000420764
ENST00000473941
C9JBV2
Show all »
Show » 285 33.2 No 6
KCNT1-201 ENSP00000263604
ENST00000263604
Q5JUK3
Show all »
Show » Show » 1230 138.3 No 8