AKAP10

GENERAL INFORMATION

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Gene name

AKAP10

Gene description

A kinase (PRKA) anchor protein 10

Protein class

Disease related genes
Mitochondrial proteins
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression, most abundant in a subset of lymphocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA028901
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

AKAP10 (HGNC Symbol)

Synonyms

D-AKAP2, MGC9414, PRKA10

Description

A kinase (PRKA) anchor protein 10 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]

Chromosome

17

Cytoband

p11.2

Chromosome location (bp)

19904302 - 19978343

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000108599 (version 78.38)

Entrez gene

11216

UniProt

O43572 (UniProt - Evidence at protein level)

neXtProt

NX_O43572

Antibodypedia

AKAP10 antibodies


PROTEIN BROWSER

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ENST00000225737
 
ENST00000395536
 
ENST00000576896
 
ENST00000583951
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKAP10-001 ENSP00000225737
ENST00000225737
O43572
Show all »
Show » Show » 662 73.8 No 0
AKAP10-005 ENSP00000378907
ENST00000395536
E7EMD6
Show all »
Show » Show » 604 67.8 No 0
AKAP10-008 ENSP00000458637
ENST00000576896
I3L177
Show all »
Show » 138 15.9 No 0
AKAP10-013 ENSP00000463398
ENST00000583951
J3QL61
Show all »
Show » 78 8.8 Yes 0