DLX4

GENERAL INFORMATION

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Gene name

DLX4

Gene description

Distal-less homeobox 4

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (placenta)
GTEx:Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein localization

RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA059933
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (placenta)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (skin)

Organ

Expression



GENE INFORMATION

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Gene name

DLX4 (HGNC Symbol)

Synonyms

BP1, DLX7, DLX8, DLX9

Description

Distal-less homeobox 4 (HGNC Symbol)

Entrez gene summary

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.33

Chromosome location (bp)

49968970 - 49974959

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000108813 (version 78.38)

Entrez gene

1748

UniProt

Q92988 (UniProt - Evidence at protein level)

neXtProt

NX_Q92988

Antibodypedia

DLX4 antibodies


PROTEIN BROWSER

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ENST00000240306
 
ENST00000411890
 
ENST00000611342
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DLX4-001 ENSP00000240306
ENST00000240306
Q92988
Show all »
Show » Show » 240 26.3 No 0
DLX4-003 ENSP00000410622
ENST00000411890
Q92988
Show all »
Show » Show » 168 18.9 No 0
DLX4-006 ENSP00000480366
ENST00000611342
Q92988
Show all »
Show » Show » 114 12.7 No 0