SNX15

GENERAL INFORMATION

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Gene name

SNX15

Gene description

Sorting nexin 15

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Normal tissues generally showed moderate cytoplasmic staining which in several cases was combined with nucleolar positivity. Purkinje cells displayed strong nucleolar staining while urinary bladder exhibited strong cytoplasmic positivity. Gastric mucosa, liver, parathyroid, muscle and lymphoid tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA038955
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SNX15

Synonyms

Description

Sorting nexin 15 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]

Chromosome

11

Cytoband

q13.1

Chromosome location (bp)

65027408 - 65040572

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110025 (version 78.38)

Entrez gene

29907

UniProt

Q9NRS6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NRS6

Antibodypedia

SNX15 antibodies


PROTEIN BROWSER

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ENST00000352068
 
ENST00000377244
 
ENST00000524831
 
ENST00000525648
 
ENST00000534637
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SNX15-001 ENSP00000366452
ENST00000377244
Q9NRS6
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Show » Show » 342 38.3 No 0
SNX15-002 ENSP00000316410
ENST00000352068
Q9NRS6
Show all »
Show » Show » 256 29.2 No 0
SNX15-004 ENSP00000437277
ENST00000534637
E9PMW6
Show all »
Show » Show » 217 24.9 No 0
SNX15-006 ENSP00000431690
ENST00000524831
E9PK26
Show all »
Show » Show » 192 22 No 0
SNX15-007 ENSP00000436023
ENST00000525648
E9PR81
Show all »
Show » 66 7 No 0