MAK

GENERAL INFORMATION

? »

Gene name

MAK

Gene description

Male germ cell-associated kinase

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Group enriched (fallopian tube, testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in testis and fallopian tube. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

? »

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA039092
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate



PROTEIN EXPRESSION OVERVIEW

? »
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Group enriched (fallopian tube, testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

? »

Gene name

MAK (HGNC Symbol)

Synonyms

dJ417M14.2, RP62

Description

Male germ cell-associated kinase (HGNC Symbol)

Entrez gene summary

The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Chromosome

6

Cytoband

p24.2

Chromosome location (bp)

10762723 - 10838555

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111837 (version 78.38)

Entrez gene

4117

UniProt

P20794 (UniProt - Evidence at protein level)

neXtProt

NX_P20794

Antibodypedia

MAK antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000313243
 
ENST00000354489
 
ENST00000474039
 
ENST00000536370
 
ENST00000538030
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAK-001 ENSP00000313021
ENST00000313243
P20794
Show all »
Show » Show » 623 70.6 No 0
MAK-002 ENSP00000476067
ENST00000474039
P20794
Show all »
Show » Show » 623 70.6 No 0
MAK-201 ENSP00000346484
ENST00000354489
P20794
Show all »
Show » Show » 648 73.5 No 0
MAK-202 ENSP00000442221
ENST00000536370
P20794
Show all »
Show » Show » 583 66.3 No 0
MAK-203 ENSP00000442250
ENST00000538030
Q8IXN4
Show all »
Show » Show » 457 52.6 No 0