IL12B

GENERAL INFORMATION

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Gene name

IL12B

Gene description

Interleukin 12B

Protein class

Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Not detected
GTEx:Not detected

Protein evidence

Evidence at protein level

Protein localization

Subsets of cells in lymphoid tissue, bone marrow and stroma showed strong immunoreactivity. The gastrointestinal tract, placental trophoblasts, endometrial glands, hepatocytes, renal tubules and skeletal muscle showed weak to moderate cytoplasmic positivity. Remaining normal tissues were generally negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA040970
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Not detected

Organ

Expression

GTEx dataset
RNA tissue category:  Not detected

Organ

Expression



GENE INFORMATION

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Gene name

IL12B (HGNC Symbol)

Synonyms

CLMF, CLMF2, IL-12B, NKSF, NKSF2

Description

Interleukin 12B (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q33.3

Chromosome location (bp)

159314783 - 159330887

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000113302 (version 78.38)

Entrez gene

3593

UniProt

P29460 (UniProt - Evidence at protein level)

neXtProt

NX_P29460

Antibodypedia

IL12B antibodies


PROTEIN BROWSER

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ENST00000231228
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL12B-001 ENSP00000231228
ENST00000231228
P29460
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